纹状体内和皮质内注射东莨菪碱对大鼠行为的影响。

Effects of intrastriatal and intracortical scopolamine on behavior in rats.

作者信息

Chambers L K, van Hartesveldt C

出版信息

Pharmacol Biochem Behav. 1984 Sep;21(3):471-3. doi: 10.1016/s0091-3057(84)80113-6.

Abstract

The anticholinergic drug scopolamine (20 micrograms, 30 micrograms, 40 micrograms) or its vehicle was injected unilaterally into the dorsal anterior striatum or overlying rostral neocortex in rats in order to examine the role of each region in contralateral postural deviation and stereotyped rearing. Scopolamine-induced contralateral deviation was observed in all subjects with striatal injections (p less than 0.01), and was of the same magnitude at all dose levels. Intracortical scopolamine did not induce contralateral deviation. However, stereotyped rearing was elicited from both the striatum and neocortex (p less than 0.01) at the two highest dose levels of scopolamine. Thus the mechanisms for contralateral deviation and stereotyped rearing differ both with respect to brain region and drug sensitivity.

摘要

将抗胆碱能药物东莨菪碱（20微克、30微克、40微克）或其溶媒单侧注射到大鼠背侧前纹状体或其上方的吻侧新皮层，以研究每个区域在对侧姿势偏差和刻板竖尾行为中的作用。在所有接受纹状体注射的实验对象中均观察到东莨菪碱诱导的对侧偏差（p<0.01），且在所有剂量水平下偏差程度相同。皮层内注射东莨菪碱未诱导对侧偏差。然而，在东莨菪碱的两个最高剂量水平下，纹状体和新皮层均引发了刻板竖尾行为（p<0.01）。因此，对侧偏差和刻板竖尾行为的机制在脑区和药物敏感性方面均有所不同。