Mitsuoka J C, Fleck R J
Pediatrics. 1984 Jan;73(1):64-7.
A program that calculates a value of clearance for an individual patient prior to reaching steady state in the early stages of aminophylline therapy is presented. The program is written for the Texas Instruments TI-59 programmable calculator and may be used with or without the PC-100C printer. The program can provide clinically useful information concerning projected plasma concentrations prior to reaching steady state with an accurate history of the dose administration and serum concentration determination. If the patient has not received xanthene therapy prior to admission, only one serum sample is required. If there has been prior drug exposure, a second serum sample is required. An iterative technique, which would be impractical to use without calculator assistance, is employed to make these determinations.
本文介绍了一种程序，该程序可在氨茶碱治疗早期达到稳态之前计算个体患者的清除率值。该程序是为德州仪器TI-59可编程计算器编写的，可搭配或不搭配PC-100C打印机使用。通过准确的给药史和血清浓度测定，该程序可以提供关于达到稳态之前预计血浆浓度的临床有用信息。如果患者入院前未接受过黄嘌呤治疗，则仅需一份血清样本。如果之前有过药物接触史，则需要第二份血清样本。采用了一种迭代技术来进行这些测定，若无计算器辅助，使用该技术将不切实际。
