Liebich H M, Pickert A, Tetschner B
J Chromatogr. 1984 Apr 27;289:259-66. doi: 10.1016/s0021-9673(00)95093-3.
Apart from increased concentrations of aliphatic dicarboxylic acids and phenolic aromatic acids in plasma from patients with chronic renal failure, there is large elevation of a furanoid acid, 3-carboxy-4-methyl-5-propyl-2- furanpropionic acid, and of hippuric acid. The levels of 3-hydroxy- and 4- hydroxyhippuric acid are also raised. The quantitative results are as follows: furanoid acid in hemodialysis patients, 1.4 +/- 0.6 mg/dl; in healthy individuals, 0.2 +/- 0.1 mg/dl; hippuric acid in hemodialysis patients, 9.8 +/- 6.5 mg/dl; in health individuals, 0.4 +/- 0.5 mg/dl. Both compounds are dialysable, but less effectively than creatinine and urea. The mean elimination rate of the furanoid acid is only 21%.
除了慢性肾衰竭患者血浆中脂肪族二羧酸和酚类芳香酸浓度升高外，一种呋喃酸（3-羧基-4-甲基-5-丙基-2-呋喃丙酸）和马尿酸的浓度也大幅升高。3-羟基马尿酸和4-羟基马尿酸的水平也升高。定量结果如下：血液透析患者中呋喃酸为1.4±0.6mg/dl；健康个体中为0.2±0.1mg/dl；血液透析患者中马尿酸为9.8±6.5mg/dl；健康个体中为0.4±0.5mg/dl。这两种化合物都可透析，但比肌酐和尿素的透析效果差。呋喃酸的平均清除率仅为21%。
