Mintzer D M, Andreeff M, Filippa D A, Jhanwar S C, Chaganti R S, Koziner B
Blood. 1984 Aug;64(2):415-21.
Histologic conversion of nodular lymphomas to more aggressive patterns has been well described and occurs in 15% to 40% of cases. Most conversions have involved changes from nodular to diffuse patterns and often from small to larger cell types. Conversions to undifferentiated lymphomas, but not specifically to the Burkitt's type, have infrequently been described. This report describes three cases of nodular poorly differentiated lymphocytic lymphoma that converted to a Burkitt's-like lymphoma. Conversion was associated with short survivals, increasing lactate dehydrogenase (LDH) levels, and changes in DNA stemline, RNA content, and S-phase values, as determined by flow cytometry. Karyotypes in two cases revealed a t(14;18). Surface immunoglobulin could be demonstrated on transformed Burkitt's-like cells from lymph node in one case, but in none of the cases on cells from bone marrow.
结节性淋巴瘤向更具侵袭性模式的组织学转化已被充分描述，发生率为15%至40%。大多数转化涉及从结节性模式向弥漫性模式的改变，且常从小细胞类型向大细胞类型转变。向未分化淋巴瘤的转化虽有报道，但并非特指伯基特型，此类报道较少。本报告描述了3例结节性低分化淋巴细胞淋巴瘤转化为伯基特样淋巴瘤的病例。转化与生存期短、乳酸脱氢酶（LDH）水平升高以及DNA主干线、RNA含量和S期值的变化有关，这些变化通过流式细胞术测定。2例病例的核型显示有t(14;18)。在1例病例中，可在来自淋巴结的转化伯基特样细胞上检测到表面免疫球蛋白，但在任何病例的骨髓细胞上均未检测到。
