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1
SIGNIFICANCE OF SPIRAL ORGANISMS FOUND, AFTER TREATMENT, IN LATE HUMAN AND EXPERIMENTAL SYPHILIS.治疗后在晚期人类梅毒和实验性梅毒中发现的螺旋体生物的意义。
Br J Vener Dis. 1964 Jun;40(2):81-9. doi: 10.1136/sti.40.2.81.
2
THE APPEARANCE AND PERSISTENCE OF VDRL, RPCF, AND TPI ANTIBODY DURING THE COURSE AND TREATMENT OF EXPERIMENTAL SYPHILIS IN THE RABBIT.梅毒血清试验(VDRL)、快速血浆反应素环状卡片试验(RPCF)和梅毒螺旋体抗体(TPI)在兔实验性梅毒病程及治疗过程中的出现与持续情况
J Invest Dermatol. 1964 May;42:367-71. doi: 10.1038/jid.1964.80.
3
STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. II. TREPONEMA PALLIDUM IMMOBILIZATION (TPI) ANTIBODY AND THE IMMUNE RESPONSE.实验性梅毒免疫研究。二。梅毒螺旋体制动(TPI)抗体与免疫反应。
Br J Vener Dis. 1963 Sep;39(3):199-203. doi: 10.1136/sti.39.3.199.
4
Effect of cortisone administration on host-parasite relationships in early experimental syphilis.可的松给药对早期实验性梅毒中宿主-寄生虫关系的影响。
J Immunol. 1981 Oct;127(4):1361-8.
5
Venereal spirochetosis of rabbits: eradication.兔性病螺旋体病:根除
Lab Anim Sci. 1981 Aug;31(4):379-81.
6
Venereal spirochetosis of rabbits: epizootiology.兔性病螺旋体病:流行病学
Lab Anim Sci. 1981 Aug;31(4):372-8.
7
Venereal spirochetosis of rabbits: description and diagnosis.兔性病螺旋体病:描述与诊断
Lab Anim Sci. 1981 Aug;31(4):366-71.
8
Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.早期实验性梅毒中淋巴细胞反应性的特征。I. 对有丝分裂原和梅毒螺旋体抗原的体外反应
J Immunol. 1980 Jan;124(1):454-60.
9
Diagnosis and treatment of syphilis.梅毒的诊断与治疗。
N Engl J Med. 1971 Mar 25;284(12):642-53. doi: 10.1056/NEJM197103252841205.
10
Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.青霉素治疗兔早期和晚期梅毒的长期结果。
Br J Vener Dis. 1973 Oct;49(5):413-9. doi: 10.1136/sti.49.5.413.

新西兰白兔性病螺旋体病的临床病程及治疗

Clinical course and treatment of venereal spirochaetosis in New Zealand white rabbits.

作者信息

DiGiacomo R F, Lukehart S A, Talburt C D, Baker-Zander S A, Condon J, Brown C W

出版信息

Br J Vener Dis. 1984 Aug;60(4):214-8. doi: 10.1136/sti.60.4.214.

DOI:10.1136/sti.60.4.214
PMID:6547627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1046312/
Abstract

Ten sporadic cases of venereal spirochaetosis, caused by Treponema paraluis-cuniculi, were seen in New Zealand white rabbits in two years. An equal number of males and females were affected. Females tended to have milder clinical signs than males. Lesions were usually found on the prepuce in males and the vulva in females, although the anus and skin of the perineum were also affected. Facial lesions were rare. Lesions healed in seven to 28 days in rabbits treated with penicillin. Eight rabbits had antibodies reactive in the Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), and fluorescent treponemal antibody absorbed (FTA-ABS) tests when the disease was first diagnosed. In several rabbits followed longitudinally, RPR test results became negative two to four months after antimicrobial treatment, VDRL antibody titres diminished but usually persisted at low levels, while FTA-ABS antibodies declined slowly and were still evident 12 months after treatment.

摘要

两年内,在新西兰白兔中发现了10例由兔梅毒螺旋体引起的散发性性病螺旋体病病例。雄性和雌性受影响的数量相等。雌性的临床症状往往比雄性轻。病变通常见于雄性的包皮和雌性的外阴,不过肛门和会阴皮肤也会受到影响。面部病变很少见。用青霉素治疗的兔子的病变在7至28天内愈合。首次诊断疾病时,8只兔子在性病研究实验室(VDRL)、快速血浆反应素(RPR)和荧光密螺旋体抗体吸收(FTA-ABS)试验中出现抗体反应。在几只纵向跟踪的兔子中,抗菌治疗后两到四个月,RPR检测结果变为阴性,VDRL抗体滴度降低但通常仍维持在低水平,而FTA-ABS抗体下降缓慢,治疗12个月后仍很明显。