Cunliffe-Beamer T L, Fox R R
Lab Anim Sci. 1981 Aug;31(4):379-81.
Venereal spirochetosis of rabbits, caused by Treponema cuniculi, have been observed since the 1940's in the rabbit colony maintained at The Jackson Laboratory. Treatment of individual rabbits with obvious clinical lesions using a product containing crystalline penicillin and dihydrostreptomycin caused lesions to heal but venereal spirochetosis persisted in the colony. Clinical and serological responses of rabbits receiving three subcutaneous injections of benzathine penicillin G-procaine penicillin G (either 42,000 or 84,000 IU/kg body weight/week) at 7 day intervals were monitored. Both doses were effective. Lesions healed within 2 weeks of the first treatment. Rapid plasma reagin titers declined markedly or disappeared by the sixth week after the first treatment. Based upon the above findings and results of previous epizootiological studies, a program to eradicate venereal spirochetosis from this enzootically infected colony was successfully undertaken.
自20世纪40年代以来，在杰克逊实验室饲养的兔群中观察到由兔梅毒螺旋体引起的兔性病螺旋体病。用含有结晶青霉素和双氢链霉素的产品治疗有明显临床病变的个别兔子，病变会愈合，但性病螺旋体病在兔群中持续存在。监测了每隔7天接受三次皮下注射苄星青霉素G-普鲁卡因青霉素G（42,000或84,000国际单位/千克体重/周）的兔子的临床和血清学反应。两种剂量均有效。病变在首次治疗后2周内愈合。快速血浆反应素滴度在首次治疗后第六周明显下降或消失。基于上述发现和以前的流行病学研究结果，成功实施了一项从这个地方流行感染的兔群中根除性病螺旋体病的计划。
