Cunliffe-Beamer T L, Fox R R
Lab Anim Sci. 1981 Aug;31(4):366-71.
Venereal spirochetosis of rabbits was studied in naturally infected rabbits from an enzootically infected colony containing inbred, partially inbred, and mutant bearing rabbits, and in experimentally infected rabbits from a hysterectomy-derived colony. Naturally and experimentally induced genital lesions were similar clinically and histologically. The most common site of lesions in naturally infected rabbits was the vulva or prepuce. Other sites, in descending order of frequency, were anal region, nose, eyelid, and lip. Clinical appearance of lesions varied from erythematous macules or papules to erosions, ulcers, and crusts. Histological examination of lesions confirmed the presence of erosions, ulcers, and crusts and, in addition, revealed acanthosis and infiltration of the dermis by plasma cells and macrophages. Dark field examination of scrapings from lesions was superior to several other methods for detection of Treponema cuniculi in lesions. The rapid plasma reagin test detected more infected rabbits than examination of lesions. The frequency of false positive rapid plasma reagin tests was low. The frequency of false negative reagin tests varied with the stage of disease.
对来自一个包含近交、部分近交和携带突变基因兔子的地方流行感染群体的自然感染兔子，以及来自子宫切除衍生群体的实验感染兔子的兔性病螺旋体病进行了研究。自然和实验诱导的生殖器病变在临床和组织学上相似。自然感染兔子中最常见的病变部位是外阴或包皮。其他部位按频率递减顺序为肛门区域、鼻子、眼睑和嘴唇。病变的临床表现从红斑丘疹到糜烂、溃疡和结痂不等。病变的组织学检查证实存在糜烂、溃疡和结痂，此外，还显示棘皮症以及浆细胞和巨噬细胞浸润真皮。对病变刮屑进行暗视野检查在检测病变中的兔梅毒螺旋体方面优于其他几种方法。快速血浆反应素试验检测到的感染兔子比病变检查更多。快速血浆反应素试验假阳性的频率较低。反应素试验假阴性的频率随疾病阶段而异。
