Tytgat G N, Surachno S, de Groot W P, Schellekens P T
Gastroenterology. 1977 Mar;72(3):536-40.
The case of a 38-year-old male patient with chronic recurrent oropharyngo-esophageal candidiasis since early childhood, resistant to topical therapy with nystatin, is reported. The disease had resulted in impressive oropharyngeal lesions and stricturing of the midesophagus. Extensive in vivo and in vitro immunological studies done before and after successful treatment with miconazole showed a persistent partial deficiency of the cell-mediated immune system, in particular that directed toward candida antigens. Miconazole, a new potent antifungal drug, proved effective in controlling the candidiasis, which had become resistant to conventional treatment.
报告了一例38岁男性患者，自幼年起患有慢性复发性口咽食管念珠菌病，对制霉菌素局部治疗耐药。该疾病导致了令人印象深刻的口咽病变和食管中段狭窄。在用咪康唑成功治疗前后进行的广泛体内和体外免疫学研究表明，细胞介导的免疫系统持续存在部分缺陷，尤其是针对念珠菌抗原的免疫缺陷。咪康唑是一种新型强效抗真菌药物，被证明对控制已对传统治疗产生耐药性的念珠菌病有效。
