豚鼠子宫对前列腺素的代谢，特别涉及妊娠早期黄体的维持。
The metabolism of prostaglandins by the guinea-pig uterus with particular reference to corpus luteal maintenance in early pregnancy.
作者信息
Walker F M, Poyser N L
出版信息
Br J Pharmacol. 1978 Feb;62(2):177-83. doi: 10.1111/j.1476-5381.1978.tb08443.x.
Abstract
1 Homogenized lung tissue from day 15, pregnant and non-pregnant guinea-pig metabolized exogenous prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) almost completely when incubated in Tyrode solution containing beta-nicotinamide adenine dinucleotide (NAD+). 2 Metabolism of PGE2 and PGF2alpha by homogenates of day 15, pregnant or non-pregnant, guinea-pig uteri was relatively low (8 to 20%) when incubated in Tyrode solution containing NAD+. 3 Day 15, guinea-pig conceptuses (placentae and embryos), homogenized and incubated in Tyrode solution containing NAD+, metabolized prostaglandins to a slightly greater extent (14 to 22%) than day 15, uterine tissue. 4 Addition of exogenous arachidonic acid to day 12 or day 15, pregnant, guinea-pig uterine homogenates in Tyrode solution did not increase the yield of PGF2alpha following incubation. 5 It is concluded that neither an increase in metabolism of PGF2alpha by the uterus and conceptus nor lack of precursor is responsible for the lower secretion of PGF2alpha from the day 15, pregnant, guinea-pig uterus when compared to the day 15, non-pregnant uterus.
摘要
- 来自妊娠和未妊娠豚鼠第15天的匀浆肺组织，在含有β - 烟酰胺腺嘌呤二核苷酸（NAD⁺）的台氏液中孵育时，几乎能完全代谢外源性前列腺素E2（PGE2）和前列腺素F2α（PGF2α）。2. 第15天妊娠或未妊娠豚鼠子宫匀浆在含有NAD⁺的台氏液中孵育时，PGE2和PGF2α的代谢相对较低（8%至20%）。3. 第15天豚鼠的孕体（胎盘和胚胎）匀浆后在含有NAD⁺的台氏液中孵育，其对前列腺素的代谢程度（14%至22%）比第15天的子宫组织略高。4. 向第12天或第15天妊娠豚鼠子宫匀浆的台氏液中添加外源性花生四烯酸，孵育后PGF2α的产量并未增加。5. 得出的结论是，与第15天未妊娠子宫相比，第15天妊娠豚鼠子宫PGF2α分泌较低，既不是由于子宫和孕体对PGF2α代谢增加，也不是由于缺乏前体所致。
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