猪感染鸟分枝杆菌血清型2的实验性感染。4. 来自经口接种猪的接触性感染。
Experimental infection with Mycobacterium avium, serotype 2, in pigs. 4. Contact infection from orally inoculated pigs.
作者信息
Jørgensen J B
出版信息
Acta Vet Scand. 1978;19(1):58-72. doi: 10.1186/BF03547642.
In 3 experiments, 13 pigs were inoculated orally with 0.5 mg Mycobacterium avium daily for 5 days (1 mg = 32–68×10 viable units). Five to 8 days after inoculation, 16 non-inoculated pigs were added to the inoculated pigs. Cultures from faeces showed excretion of M. avium from all the inoculated pigs for some time within the period 16 to 65 days after the last inoculation; the greatest numbers of organisms (62000 per 100 g faeces) were found at about the middle of the excretion period (Table 2). Two of the contact pigs were found to excrete M. avium in small numbers, 1 at 15, the other at 37 and 44 days after contact. All the inoculated pigs and 13 of the contact pigs showed positive intradermal tuberculin reactions. Post-mortem examination showed tuberculous lesions in all the inoculated pigs (Table 3). M. avium was transmitted to 15 of 16 pigs by contact. Five of these pigs showed gross lesions, 10 of them microscopic lesions only; in 9 of them the infection was proved by culture.
在3项实验中，13头猪每天口服接种0.5毫克鸟分枝杆菌，持续5天（1毫克 = 32 - 68×10个活单位）。接种后5至8天，将16头未接种的猪添加到已接种的猪群中。粪便培养显示，在最后一次接种后的16至65天内，所有接种猪在一段时间内都排出鸟分枝杆菌；在排泄期中期左右发现的菌量最多（每100克粪便中有62000个）（表2）。发现2头接触猪少量排出鸟分枝杆菌，1头在接触后15天，另一头在接触后37天和44天。所有接种猪和13头接触猪的皮内结核菌素反应均呈阳性。尸检显示所有接种猪都有结核病变（表3）。鸟分枝杆菌通过接触传播给了16头猪中的15头。其中5头猪有肉眼可见病变，10头只有显微镜下可见病变；其中9头猪的感染通过培养得到证实。
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