Sharma J N, Zeitlin I J, Deodhar S D, Buchanan W W
Arch Int Pharmacodyn Ther. 1983 Apr;262(2):279-86.
The synovial tissue kallikrein of rheumatoid patients, arthritic dogs and normal dogs has been partially characterized and estimated. Both human and dog synovial tissue kinin-forming enzyme appears to be distinct from plasmin, plasma kallikrein and pancreatic kallikrein. In three rheumatoid arthritic patients, the mean synovial tissue kallikrein level was found to be 106 +/- 13.5 ng bradykinin equivalents (BK Equiv) per g per min. In nine arthritic dogs the mean synovial tissue kallikrein level, 60.5 +/- 4.5 ng BK Equiv per g per min, was found to be greater (p less than 0.05) than that of five normal dogs (21.6 +/- 5.3 ng BK Equiv per g per min). The possible significance of this finding is discussed.
已对类风湿性关节炎患者、患有关节炎的犬类和正常犬类的滑膜组织激肽释放酶进行了部分特性鉴定和评估。人类和犬类滑膜组织激肽形成酶似乎与纤溶酶、血浆激肽释放酶和胰激肽释放酶不同。在三名类风湿性关节炎患者中，滑膜组织激肽释放酶的平均水平为每克每分钟106±13.5纳克缓激肽当量（BK当量）。在九只患有关节炎的犬类中，滑膜组织激肽释放酶的平均水平为每克每分钟60.5±4.5纳克BK当量，发现该水平高于五只正常犬类（每克每分钟21.6±5.3纳克BK当量）（p<0.05）。讨论了这一发现的可能意义。
