Becker B, Palmberg F, Shin D H
Invest Ophthalmol Vis Sci. 1977 Jan;16(1):61-3.
Primary open-angle galucoma (POAG) patients are more responsive to glucocorticoids, and have increased prevalences of the histocompatibility antigens HLA-B7 and HLA-B12. We report herein a comparison of in vitro cellular responsiveness to glucocorticoids and HLA classification for 25 POAG patients, and 25 individuals who respond to topical dexamethasone with intraocular pressure is greater than 31 mm. HG. (GG responders). Within both the POAG and GG groups, significantly greater responsiveness to prednisolone occurs in patients with HLA-B12 antigen. No such association occurs for patients with HLA-B7.
原发性开角型青光眼（POAG）患者对糖皮质激素更敏感，并且组织相容性抗原HLA - B7和HLA - B12的患病率增加。我们在此报告了25例POAG患者以及25例局部使用地塞米松后眼压升高超过31 mmHg的个体（糖皮质激素高反应者，GG）对糖皮质激素的体外细胞反应性和HLA分类的比较。在POAG组和GG组中，HLA - B12抗原阳性的患者对泼尼松龙的反应性明显更高。而HLA - B7阳性的患者则无此关联。
