HLA - B7和HLA - B12抗原与杯盘比、青光眼家族史及眼压的关联

The association of HLA-B7 and HLA-B12 antigens with cup/disk ratio, family history of glaucoma, and intraocular pressure.

作者信息

Shin D H, Kass M A, Becker B

出版信息

Am J Ophthalmol. 1977 Mar;83(3):347-9. doi: 10.1016/0002-9394(77)90731-0.

Abstract

The presence of either HLA-B7 or HLA-B12 antigens was associated with a higher prevalence of cup/disk ratios greater than 0.3 in the GG responders (intraocular pressure greater than 31 mm Hg after six weeks of topical dexamethasone 0.1%, four times daily) and in the combined NN-NG (intraocular pressure less than or equal to 31 mm Hg) groups. The presence of either antigen was associated with a higher prevalence of a family history of glaucoma in the GG group. N association was noted between the antigens and age, sex, race, or mean intraocular pressure in either of the groups studied.

摘要

在GG反应者（每天4次局部使用0.1%地塞米松6周后眼压大于31 mmHg）以及联合的NN-NG组（眼压小于或等于31 mmHg）中，HLA - B7或HLA - B12抗原的存在与杯盘比大于0.3的较高患病率相关。在GG组中，这两种抗原中任何一种的存在都与青光眼家族史的较高患病率相关。在所研究的任何一组中，均未发现这些抗原与年龄、性别、种族或平均眼压之间存在关联。