Wagner J A, Horvath S M, Andrew G M, Cottle W H, Bedi J F
Aviat Space Environ Med. 1978 Jun;49(6):785-91.
Six nonsmokers and six cigarette smokers, 22-34 years old, performed bicycle work (53% sea level VO2 max) for 30 min in an altitude chamber under four conditions: SL, simulated sea level (PIO2 = 159 torr, PB = 523 torr) with 0.5% HbCO; SLCO, simulated sea level with 4.2% HbCO; and ACO, altitude with 4.2% HbCO. During work at altitude, heart rate (HR), minute ventilation and tidal volume increased and diastolic blood pressures decreased relative to SL. Cardiac output (Qc), stroke volume (SV), and arterial-mixed venous oxygen difference (a--vO2) were similar in smokers and nonsmokers at SL, SLCO, and A. At ACO, nonsmokers increased Qc and SV and decreased a--vO2, but these were not influenced in the smokers. Smokers showed a graded increase in HR when exposed to work in SLCO, A, and ACO. Their lower finger temperatures during A and ACO suggested vasoconstriction in the extremities. Cigarette smokers may be partially adapted to hypoxia.
6名不吸烟者和6名吸烟者，年龄在22至34岁之间，在海拔舱内的四种条件下进行了30分钟的自行车运动（53%海平面最大摄氧量）：SL，模拟海平面（吸入氧分压=159托，气压=523托），一氧化碳血红蛋白含量为0.5%；SLCO，模拟海平面，一氧化碳血红蛋白含量为4.2%；以及ACO，海拔高度，一氧化碳血红蛋白含量为4.2%。在海拔高度运动期间，与海平面相比，心率（HR）、每分通气量和潮气量增加，舒张压降低。在海平面、SLCO和ACO条件下，吸烟者和不吸烟者的心输出量（Qc）、每搏输出量（SV）以及动脉-混合静脉血氧差（a-vO2）相似。在ACO条件下，不吸烟者增加了Qc和SV，降低了a-vO2，但吸烟者未受影响。吸烟者在SLCO、ACO和ACO条件下进行运动时，心率呈分级增加。在ACO和ACO条件下，他们较低的手指温度表明四肢血管收缩。吸烟者可能对低氧有部分适应性。
