金黄色葡萄球菌宏稀释法最低杀菌浓度（MBC）的不可重复性。
Lack of reproducibility of macrodilution MBCs for Staphylococcus aureus.
作者信息
Pelletier L L
出版信息
Antimicrob Agents Chemother. 1984 Dec;26(6):815-8. doi: 10.1128/AAC.26.6.815.
Abstract
MBCs of methicillin, oxacillin, penicillin G, cephalothin, vancomycin, and gentamicin were determined by a standard broth macrodilution technique for 101 clinical isolates of methicillin-susceptible Staphylococcus aureus. Increased killing (more than 99.9%) was observed after 48 versus 24 h of incubation for many strains, and cross tolerance to antimicrobial bactericidal activity (less than 99.9% killing) was frequently observed among antimicrobial agents. However, these in vitro measurements of bactericidal activity against S. aureus were not reproducible.
摘要
采用标准肉汤稀释法，对101株甲氧西林敏感金黄色葡萄球菌临床分离株测定了甲氧西林、苯唑西林、青霉素G、头孢噻吩、万古霉素和庆大霉素的最低杀菌浓度（MBC）。许多菌株在培养48小时后比24小时后观察到杀菌作用增强（超过99.9%），并且在抗菌药物之间经常观察到对杀菌活性的交叉耐受性（杀菌率低于99.9%）。然而，这些针对金黄色葡萄球菌的体外杀菌活性测定结果不可重复。
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