pH 依赖性青霉素耐受性可能保护白细胞内的金黄色葡萄球菌免受氯唑西林的杀灭。
pH-dependent penicillin tolerance may protect intraleukocytic Staphylococcus aureus from killing by cloxacillin.
作者信息
Craven N, Anderson J C
出版信息
Antimicrob Agents Chemother. 1982 Apr;21(4):618-21. doi: 10.1128/AAC.21.4.618.
Abstract
Exposure of Staphylococcus aureus to cloxacillin at neutral pH rendered the bacteria more susceptible to subsequent lysis by lysostaphin. This sensitization effect also occurred at lower pH levels which were nonpermissive for the bactericidal action of cloxacillin, but the effect disappeared at pH 5.0. These findings elucidate previous observations on the protection of intraleukocytic S. aureus from killing by cloxacillin and indicate that low pH in the phagolysosomes may be involved.
摘要
在中性pH值下，金黄色葡萄球菌暴露于氯唑西林会使细菌对随后的溶葡萄球菌素裂解更敏感。这种致敏作用在较低pH值下也会发生，而该pH值对氯唑西林的杀菌作用无效，但在pH 5.0时该作用消失。这些发现阐明了先前关于保护白细胞内金黄色葡萄球菌免受氯唑西林杀伤的观察结果，并表明吞噬溶酶体中的低pH值可能与之有关。
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