Blot W J, Winn D M, Fraumeni J F
J Natl Cancer Inst. 1983 Feb;70(2):251-3.
As part of a case-control study in North Carolina involving 206 women with oral and pharyngeal cancers and 352 controls, questions were asked concerning the patterns of mouthwash use. No significant overall increase in risk was found among users; the relative risk, adjusted for snuff dipping and smoking habits, was 1.15 [lower, upper limits of the 95% confidence interval (95% Cl) = 0.8, 1.7]. The relative risk associated with mouthwash use was increased to 1.94 (95% Cl = 0.8, 4.7), however, among women abstaining from tobacco. Although consistent dose-response relationships were not observed for this subgroup, these findings and other reports of an increased risk among persons ordinarily at low risk of this disease raise the possibility that mouthwash may contribute to oral and pharyngeal cancers.
作为北卡罗来纳州一项病例对照研究的一部分，该研究涉及206名口腔和咽癌女性患者及352名对照者，研究人员询问了她们使用漱口水的模式。在使用者中未发现总体风险有显著增加；在对鼻烟蘸吸和吸烟习惯进行调整后，相对风险为1.15[95%置信区间（95%Cl）的下限、上限=0.8，1.7]。然而，在不吸烟的女性中，与使用漱口水相关的相对风险增加到了1.94（95%Cl=0.8，4.7）。尽管该亚组未观察到一致的剂量反应关系，但这些发现以及其他关于通常患此病风险较低人群中风险增加的报告，增加了漱口水可能导致口腔和咽癌的可能性。
