Kabat G C, Hebert J R, Wynder E L
Division of Epidemiology, American Health Foundation, New York, New York 10017.
Cancer Res. 1989 May 15;49(10):2803-6.
Interviews were obtained from 125 women with oral cavity cancer and 107 female controls to assess the role of mouthwash use as a risk factor for oral cancer in women. In addition to detailed information on mouthwash use throughout adult life, information was obtained regarding smoking, alcohol consumption, general oral hygiene practices, and occurrence of nonmalignant conditions of the oral cavity. Mouthwash use was not associated with increased oral cancer risk in terms of frequency, duration of use, dilution, or rinsing practices. Among mouthwash users, cases reported taking more mouthfuls of mouthwash at each use compared with controls. Again among mouthwash users, cases were significantly more likely than controls to give as a reason for using mouthwash "to disguise the smell of tobacco" and "to disguise the smell of alcohol," whereas similar proportions of cases and controls reported using mouthwash to "disguise the smell of onions, garlic, etc." and "to disguise breath odors due to mouth infections or dental problems." These first two reasons for using mouthwash were strongly associated with smoking and drinking, respectively, and appear to be proxies for these exposures. Smoking, drinking, having 10 or more missing teeth, and religious background (non-Jewish versus Jewish) were significantly associated with oral cancer.
对125名口腔癌女性患者和107名女性对照者进行了访谈，以评估使用漱口水作为女性口腔癌危险因素的作用。除了关于成年后使用漱口水的详细信息外，还获取了有关吸烟、饮酒、一般口腔卫生习惯以及口腔非恶性疾病发生情况的信息。就使用频率、使用持续时间、稀释情况或漱口方式而言，使用漱口水与口腔癌风险增加无关。在使用漱口水的人群中，与对照者相比，病例组报告每次使用漱口水时的含漱量更多。同样在使用漱口水的人群中，病例组比对照者更有可能将“掩盖烟草气味”和“掩盖酒精气味”作为使用漱口水的原因，而病例组和对照者中报告使用漱口水“掩盖洋葱、大蒜等气味”以及“掩盖口腔感染或牙齿问题引起的口气异味”的比例相似。使用漱口水的前两个原因分别与吸烟和饮酒密切相关，似乎是这些暴露因素的替代指标。吸烟、饮酒、缺牙10颗或更多以及宗教背景（非犹太人与犹太人）与口腔癌显著相关。
