Wynder E L, Kabat G, Rosenberg S, Levenstein M
J Natl Cancer Inst. 1983 Feb;70(2):255-60.
The role of mouthwash and other factors was examined in relation to oral cavity cancer by means of a retrospective study. Daily use of mouthwash showed an excess risk in females but no excess risk in males. No dose response was seen in females with increased duration of use. In nonsmoking, nondrinking women as well, daily mouthwash use was associated with excess risk. Multiple logistic regression including all factors of interest showed inconsistent results for duration and frequency of mouthwash use. Due to the absence of a dose-response relationship and the possibility of confounding by tobacco and alcohol use, it was not possible to attribute causal significance to the association between daily mouthwash use and oral cancer in women.
通过一项回顾性研究，对漱口水及其他因素与口腔癌的关系进行了调查。每日使用漱口水在女性中显示出额外风险，但在男性中未显示出额外风险。在女性中，未观察到使用时间延长的剂量反应。在不吸烟、不饮酒的女性中，每日使用漱口水也与额外风险相关。纳入所有相关因素的多元逻辑回归分析显示，漱口水使用时间和频率的结果不一致。由于缺乏剂量反应关系以及存在烟草和酒精使用造成混杂的可能性，无法将每日使用漱口水与女性口腔癌之间的关联归因于因果关系。
