Fernandes G, Alonso D R, Tanaka T, Thaler H T, Yunis E J, Good R A
Proc Natl Acad Sci U S A. 1983 Feb;80(3):874-7. doi: 10.1073/pnas.80.3.874.
Autoimmune-prone B/W mice, which are known to develop severe glomerulonephritis and vasculitis, also are found to develop arteritis and proliferative and fatty-proliferative lesions of the aorta and its branches as well as renal inflammatory lesions. High intake of saturated fat in the diet enhances the development of these atherosclerotic and autoimmune lesions significantly in female mice, whereas restriction of dietary calories and fat inhibits their development. Ad lib feeding of laboratory chow, high in fiber and low in fat, does not foster development of vascular lesions but does permit the development of autoimmune renal disease.
易患自身免疫性疾病的B/W小鼠，已知会发展为严重的肾小球肾炎和血管炎，还被发现会出现动脉炎以及主动脉及其分支的增生性和脂肪增生性病变，以及肾脏炎症性病变。饮食中高饱和脂肪摄入显著增强了雌性小鼠这些动脉粥样硬化和自身免疫性病变的发展，而限制饮食热量和脂肪则会抑制其发展。随意喂食高纤维、低脂肪的实验室饲料不会促进血管病变的发展，但会使自身免疫性肾病得以发展。
