NZB/BL小鼠的免疫病理学。V. 可从淋巴瘤细胞中分离出来并通过电子显微镜鉴定的类病毒（可过滤）因子。
Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy.
作者信息
Mellors R C, Huang C Y
出版信息
J Exp Med. 1966 Dec 1;124(6):1031-8. doi: 10.1084/jem.124.6.1031.
Abstract
A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys-renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice. Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites. The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.
摘要
从NZB/Bl小鼠可移植性恶性淋巴瘤中分离出的一种可滤过因子，接种到断奶前的NZB/Bl小鼠后，能够诱导淋巴细胞增生、高球蛋白血症、蛋白尿、低白蛋白血症以及肾脏的病理变化（局灶性膜性肾小球肾炎）——肾脏的功能和结构变化在性质上与老年NZB/Bl小鼠自发出现的变化相似。通过电子显微镜在NZB/Bl小鼠组织和细胞中鉴定出了与典型的“C”型鼠致癌病毒颗粒极为相似的病毒样颗粒，这些组织和细胞包括恶性淋巴瘤细胞、胸腺和脾脏的良性淋巴细胞、肾小管上皮细胞以及细胞外部位。本文首次报道了与NZB/Bl小鼠相关的这些观察结果，并结合该品系小鼠所特有的几种免疫病理紊乱情况进行了讨论。
相似文献
1
Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy.NZB/BL小鼠的免疫病理学。V. 可从淋巴瘤细胞中分离出来并通过电子显微镜鉴定的类病毒（可过滤）因子。
J Exp Med. 1966 Dec 1;124(6):1031-8. doi: 10.1084/jem.124.6.1031.
2
Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice.NZB/BL小鼠的免疫病理学。VI. 可从脾脏分离出且对瑞士小鼠致病的病毒。
J Exp Med. 1967 Jul 1;126(1):53-62. doi: 10.1084/jem.126.1.53.
3
Autoimmune disease in NZB/BL mice. 3. Induction of membranous glomerulonephritis in young mice by the transplantation of spleen cells from old mice.NZB/BL小鼠的自身免疫性疾病。3. 通过移植老年小鼠的脾细胞诱导幼年小鼠发生膜性肾小球肾炎。
J Exp Med. 1966 Jun 1;123(6):1025-34. doi: 10.1084/jem.123.6.1025.
4
Further implication of murine leukemia-like virs in the disorders of NZB mice.鼠白血病样病毒在新西兰黑小鼠疾病中的进一步影响。
J Exp Med. 1969 May 1;129(5):1045-62. doi: 10.1084/jem.129.5.1045.
5
Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus.小鼠白血病病毒的免疫致病性和致癌性。I. 斯克里普斯白血病病毒在（BALB-c×NZB）F1小鼠中诱导免疫性疾病和淋巴瘤。
J Exp Med. 1974 Oct 1;140(4):1028-48. doi: 10.1084/jem.140.4.1028.
6
Autoimmune disease in NZB-Bl mice. II. Autoimmunity and malignant lymphoma.NZB-Bl小鼠的自身免疫性疾病。II.自身免疫与恶性淋巴瘤。
Blood. 1966 Apr;27(4):435-48.
7
[Aspects of megakaryocytic viral production in relation to lymphocytic leukemia in the rat].[大鼠巨核细胞病毒产生与淋巴细胞白血病相关的若干方面]
C R Seances Soc Biol Fil. 1982;176(1):109-14.
8
Transmission of auto-immune haemolytic anaemia and murine leukaemia virus in NZB-BALB/c hybrid mice.NZB-BALB/c 杂交小鼠中自身免疫性溶血性贫血和鼠白血病病毒的传播
Clin Exp Immunol. 1976 Apr;24(1):196-209.
9
10
Rapid viral induction of murine lymphomas in the graft-versus-host reaction.移植物抗宿主反应中病毒对小鼠淋巴瘤的快速诱导
J Exp Med. 1972 Dec 1;136(6):1533-44. doi: 10.1084/jem.136.6.1533.
引用本文的文献
1
Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus.正常人和系统性红斑狼疮患者血浆DNA的定量与特征分析。
J Clin Invest. 1980 Dec;66(6):1391-9. doi: 10.1172/JCI109992.
2
Clq deposits at the dermoepidermal junction: a marker discriminating for discoid and systemic lupus erythematosus.Clq沉积于真皮表皮交界处：一种区分盘状红斑狼疮和系统性红斑狼疮的标志物。
J Clin Immunol. 1981 Apr;1(2):119-24. doi: 10.1007/BF00915389.
3
Influence of diet on vascular lesions in autoimmune-prone B/W mice.饮食对自身免疫易感B/W小鼠血管病变的影响。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):874-7. doi: 10.1073/pnas.80.3.874.
4
Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice.NZB/BL小鼠的免疫病理学。VI. 可从脾脏分离出且对瑞士小鼠致病的病毒。
J Exp Med. 1967 Jul 1;126(1):53-62. doi: 10.1084/jem.126.1.53.
5
Normal induction and maintenance of tolerance in (NZBxNZW) F1 mice.（新西兰黑鼠×新西兰白鼠）F1代小鼠中耐受性的正常诱导与维持。
Clin Exp Immunol. 1969 Sep;5(3):265-72.
6
Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse.2月龄新西兰黑小鼠对绵羊红细胞的7S抗体反应增强。
Clin Exp Immunol. 1969 Sep;5(3):251-63.
7
Naturally occurring haemagglutinins in the New Zealand black mouse.新西兰黑鼠体内天然存在的血凝素。
Clin Exp Immunol. 1969 Apr;4(4):453-6.
8
The incidence of spontaneously occurring anti-liver antibodies in New Zealand black mice.新西兰黑鼠中自发产生抗肝抗体的发生率。
Immunology. 1969 Apr;16(4):537-41.
9
Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease.在易患自身免疫性疾病的小鼠品系中，随着年龄增长，细胞免疫在体外逐渐丧失。
Clin Exp Immunol. 1971 Sep;9(3):305-11.
10
Immunopathological basis of some connective tissue disorders.一些结缔组织疾病的免疫病理学基础。
Br Med J. 1971 Dec 4;4(5787):601-3. doi: 10.1136/bmj.4.5787.601.
本文引用的文献
1
"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.在婴儿期接种AK白血病提取物或AK胚胎后，C3H小鼠中发生的“自发性”白血病。
Proc Soc Exp Biol Med. 1951 Jan;76(1):27-32.
2
A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia.一种由病毒引起的小鼠疾病，其特征为红细胞生成和淋巴白血病。
J Natl Cancer Inst. 1962 Sep;29:515-43.
3
Reaction of the reticular tissue of mice with autoimmune haemolytic anaemia to 2-aminofluorene.自身免疫性溶血性贫血小鼠的网状组织对2-氨基芴的反应
Nature. 1962 May 19;194:692. doi: 10.1038/194692a0.
4
COOMBS TEST CONVERSION IN YOUNG NZB MICE INDUCED BY TRANSFER OF LYMPHOID CELLS FROM COOMBS POSITIVE DONORS.由来自库姆斯阳性供体的淋巴细胞转移诱导的年轻新西兰黑小鼠的库姆斯试验转化
Aust J Exp Biol Med Sci. 1965 Jul;43:399-404. doi: 10.1038/icb.1965.73.
5
AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS.NZB/BL小鼠的自身免疫性疾病。I. 自发性肾小球肾炎模型系统的病理学与发病机制
J Exp Med. 1965 Jul 1;122(1):25-40. doi: 10.1084/jem.122.1.25.
6
7
AUTOANTIBODIES PRODUCED AGAINST MOUSE ERYTHROCYTES IN NZB MICE.NZB小鼠体内产生的针对小鼠红细胞的自身抗体。
Aust J Exp Biol Med Sci. 1963 Aug;41:315-22. doi: 10.1038/icb.1963.31.
8
Spontaneous auto-immune disease in NZB/BL mice.NZB/BL小鼠的自发性自身免疫疾病。
Br J Haematol. 1963 Apr;9:119-31. doi: 10.1111/j.1365-2141.1963.tb05450.x.
9
Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice.与小鼠杂交品系中狼疮红斑试验阳性相关的肾脏疾病
Nature. 1963 Jan 12;197:197. doi: 10.1038/197197a0.
10
The detection and study of tumor viruses with the electron microscope.利用电子显微镜对肿瘤病毒进行检测与研究。
Cancer Res. 1960 Jun;20:712-27.
Zotero 插件