Mellors R C, Huang C Y
J Exp Med. 1966 Dec 1;124(6):1031-8. doi: 10.1084/jem.124.6.1031.
A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys-renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice. Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites. The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.
从NZB/Bl小鼠可移植性恶性淋巴瘤中分离出的一种可滤过因子，接种到断奶前的NZB/Bl小鼠后，能够诱导淋巴细胞增生、高球蛋白血症、蛋白尿、低白蛋白血症以及肾脏的病理变化（局灶性膜性肾小球肾炎）——肾脏的功能和结构变化在性质上与老年NZB/Bl小鼠自发出现的变化相似。通过电子显微镜在NZB/Bl小鼠组织和细胞中鉴定出了与典型的“C”型鼠致癌病毒颗粒极为相似的病毒样颗粒，这些组织和细胞包括恶性淋巴瘤细胞、胸腺和脾脏的良性淋巴细胞、肾小管上皮细胞以及细胞外部位。本文首次报道了与NZB/Bl小鼠相关的这些观察结果，并结合该品系小鼠所特有的几种免疫病理紊乱情况进行了讨论。
