Blake N M, Kirk R L, Wilson S R, Garruto R M, Gajdusek D C, Gibbs C J, Hoffman P
Am J Med Genet. 1983 Feb;14(2):299-305. doi: 10.1002/ajmg.1320140210.
Frequency distributions were determined for 24 red cell enzyme and four serum protein systems, in an attempt to identify a genetic marker associated with either amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia (PD), two progressive and fatal neurological disorders of unknown cause found with unusually high incidence among the Chamorros of Guam and the Northern Mariana Islands. No striking associations were identified between either disorder and any of the gene markers tested. Thus, no genetic cause is known for either disease; local environmental factors are most likely involved in pathogenesis.
确定了24种红细胞酶和4种血清蛋白系统的频率分布，试图找出与肌萎缩侧索硬化症（ALS）或帕金森痴呆症（PD）相关的遗传标记，这两种进行性致命性神经疾病病因不明，在关岛和北马里亚纳群岛的查莫罗人当中发病率异常高。未发现这两种疾病与任何测试的基因标记之间存在显著关联。因此，这两种疾病的遗传病因均不明；发病机制很可能涉及当地环境因素。
