Garruto R M, Gajdusek D C, Chen K M
Ann Neurol. 1981 Oct;10(4):341-50. doi: 10.1002/ana.410100405.
Amyotrophic lateral sclerosis (ALS) has occurred in 9 Filipino migrants to Guam 1 to 29 years after their arrival and parkinsonism-dementia (PD) in 2 migrants 13 and 26 years after arrival. Seven additional Filipino patients developed more classic Parkinson disease (P) 5 to 24 years after their migration to Guam. Furthermore, 10 part-Filipino patients who were born on Guam of Filipino and Chamorro parentage developed ALS, while 6 such part-Filipino patients developed PD. An estimate of the average annual crude mortality rate for ALS among Filipino migrants was approximately six times that of the continental United States, yet half that currently observed among Chamorros living on Guam. A majority of all migrant patients were born in northwestern Luzon in the Philippine Islands, indicating the desirability of an intensive field epidemiological investigation in that area.
9名菲律宾移民在抵达关岛1至29年后出现肌萎缩侧索硬化症（ALS），2名移民在抵达13年和26年后出现帕金森痴呆症（PD）。另外7名菲律宾患者在移民到关岛5至24年后患上了更典型的帕金森病（P）。此外，10名出生在关岛、父母为菲律宾人和查莫罗人的部分菲律宾裔患者患上了ALS，而6名这样的部分菲律宾裔患者患上了PD。据估计，菲律宾移民中ALS的年平均粗死亡率约为美国大陆的6倍，但仅为目前居住在关岛的查莫罗人的一半。所有移民患者中的大多数出生在菲律宾群岛的吕宋岛西北部，这表明在该地区进行深入的现场流行病学调查是可取的。
