Brody J A, Stanhope J M, Kurland L T
Contemp Neurol Ser. 1975;12:45-70.
The striking concentration of amyotrophic lateral sclerosis (ALS) and parkinsonismdementia (PD) among the Chamorro people of Guam has attracted attention since the early 1950's. Extensive studies conducted over the past 20 years have not revealed the causes of these diseases and the reasons for their remarkable concentrations on Guam. Approximately 1 in 10 Guamanian deaths over age 25 is from ALS, and another 1 in 10 is from PD. ALS still occurs approximately 50 times more frequently on Guam than in the continental United States. Advances in virologic and biochemical techniques, and long years of study, appear to be leading us to a point where some of the problems will be resolved. We shall attempt to review the pertinent background information and summarize the data and observations up to the present time.
自20世纪50年代初以来，关岛查莫罗人肌萎缩侧索硬化症（ALS）和帕金森病痴呆症（PD）的显著集中发病现象就引起了关注。过去20年进行的广泛研究尚未揭示这些疾病的病因以及它们在关岛显著集中发病的原因。25岁以上的关岛人中，约十分之一死于ALS，另有十分之一死于PD。ALS在关岛的发病率仍比美国大陆高约50倍。病毒学和生化技术的进步以及多年的研究，似乎正引领我们走向一些问题将得到解决的阶段。我们将尝试回顾相关背景信息，并总结截至目前的数据和观察结果。
