Howe G R, Fraser D, Lindsay J, Presnal B, Yu S Z
J Natl Cancer Inst. 1983 Jun;70(6):1015-9.
A cohort study of 43,826 male pensioners of the Canadian National Railway Company was conducted. The cause of death of 17,838 pensioners who died between 1965 and 1977 was ascertained by computerized record linkage to the Canadian national mortality data base. The main finding was an elevated risk of lung cancer for those employed in occupations involving exposure to diesel fumes and coal dust, with highly significant dose-response relationships observed. That such association may be due in part to smoking cannot be excluded; but in view of the widespread exposure to diesel fumes, the finding warrants further investigation. The present study also demonstrated the utility and feasibility of large-scale occupational cohort studies conducted with the use of computerized record linkage to national mortality records.
对加拿大国家铁路公司的43826名男性退休人员进行了一项队列研究。通过计算机化记录与加拿大国家死亡率数据库的关联，确定了1965年至1977年间死亡的17838名退休人员的死因。主要发现是，从事接触柴油烟雾和煤尘职业的人员患肺癌的风险升高，观察到了高度显著的剂量反应关系。不能排除这种关联可能部分归因于吸烟；但鉴于柴油烟雾的广泛接触，这一发现值得进一步调查。本研究还证明了利用计算机化记录与国家死亡率记录进行大规模职业队列研究的实用性和可行性。
