惊恐发作患者对冷加压试验的催乳素反应。

Prolactin response to the cold pressor test in patients with panic attacks.

作者信息

Grunhaus L, Gloger S, Birmacher B, Palmer C, Ben-David M

出版信息

Psychiatry Res. 1983 Mar;8(3):171-7. doi: 10.1016/0165-1781(83)90060-4.

Abstract

Recent advances in psychiatric nosology have provided a clearer clinical description of panic disorder and agoraphobia with panic attacks. This clinical improvement has yet to result in a better understanding of the basic mechanisms involved in these conditions. The present study compares the effects of the cold pressor test on blood pressure changes and prolactin levels in patients with panic disorder and agoraphobia with panic attacks to its effects in normal controls. Because the effects of the cold pressor test were similar in patients and normal controls, it appears that alpha-adrenergic function is normal in the patient group. The results also suggest that prolactin hypersecretion does not occur in pathological anxiety states.

摘要

近期精神疾病分类学的进展对惊恐障碍以及伴有惊恐发作的广场恐惧症给出了更清晰的临床描述。这一临床方面的改善尚未带来对这些病症所涉及的基本机制的更深入理解。本研究比较了冷加压试验对惊恐障碍患者以及伴有惊恐发作的广场恐惧症患者的血压变化和催乳素水平的影响，与该试验对正常对照组的影响。由于冷加压试验在患者组和正常对照组中的效果相似，看来患者组的α - 肾上腺素能功能是正常的。研究结果还表明，病理性焦虑状态下不会发生催乳素分泌过多的情况。