Maguire K, McIntyre I, Norman T, Burrows G D
Psychiatry Res. 1983 Apr;8(4):281-7. doi: 10.1016/0165-1781(83)90016-1.
The pharmacokinetics of mianserin were examined in eight elderly depressed patients following a single oral dose of 60 mg. Plasma concentrations were measured by gas chromatography/mass spectrometry and the data analyzed using a two-compartment open model. Mean (+/- SD) estimates were: absorption half-life 0.8 +/- 1.0h, peak concentration 117 +/- 23 micrograms/l, peak time 2.2 +/- 1.3h, distribution half-life 3.4 +/- 1.2h, elimination half-life 33 +/- 15h, apparent volume of distribution 20.2 +/- 7.9 1/kg, and oral clearance 0.49 +/- 0.21 l/kg/h. These parameters were not significantly different from those found in healthy volunteers. The absorption lag time (0.6 +/- 0.2h) and area under the curve (2009 +/- 566 micrograms/l/h) were significantly different in the elderly. The clinical implications of these differences for the treatment of elderly depressed patients are discussed.
对8名老年抑郁症患者单次口服60毫克米安色林后的药代动力学进行了研究。采用气相色谱/质谱法测定血浆浓度，并使用二室开放模型分析数据。平均（±标准差）估计值为：吸收半衰期0.8±1.0小时，峰值浓度117±23微克/升，达峰时间2.2±1.3小时，分布半衰期3.4±1.2小时，消除半衰期33±15小时，表观分布容积20.2±7.9升/千克，口服清除率0.49±0.21升/千克/小时。这些参数与健康志愿者的参数无显著差异。老年患者的吸收滞后时间（0.6±0.2小时）和曲线下面积（2009±566微克/升/小时）有显著差异。讨论了这些差异对老年抑郁症患者治疗的临床意义。
