米安色林的药代动力学研究。
A pharmacokinetic study of mianserin.
作者信息
Maguire K P, Norman T R, Burrows G D, Scoggins B A
出版信息
Eur J Clin Pharmacol. 1982;21(6):517-20. doi: 10.1007/BF00542048.
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 microgram/1 at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3-2.8), (t1/2) alpha 2.5 h (0.9-4.7), (t1/2) beta 21 h (14-33), (Vd) beta 27.5 l/kg (16.8-46.5) and Cloral 0.98 l/kg/h (0.47-1.75). Blood/plasma concentration ratios ranged from 0.50-0.74.
在8名健康男性志愿者单次口服60毫克米安色林后，对其动力学进行了评估。采用气相色谱 - 质谱碎片分析法测定米安色林的血浆和血液浓度。给药后3小时观察到的血药浓度峰值为65微克/升。根据血药浓度计算的平均动力学参数（及范围）为：吸收半衰期（t1/2）abs 1.1小时（0.3 - 2.8），分布相半衰期（t1/2）α 2.5小时（0.9 - 4.7），消除相半衰期（t1/2）β 21小时（14 - 33），β相表观分布容积（Vd）β 27.5升/千克（16.8 - 46.5），总体清除率（Cloral）0.98升/千克/小时（0.47 - 1.75）。血药/血浆浓度比范围为0.50 - 0.74。
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