Lugg M A, Nicholas T E
Biol Neonate. 1983;44(1):42-8. doi: 10.1159/000241693.
We have examined the rate of disappearance and the form of the radiolabel following the injection of either [1,2-3H]-cortisone (3H-E) or [1,2,6,7,n-3H]-cortisol (3H-F) into the amniotic sac of rabbits at day 25 of gestation. The half-life of 3H-E was approximately 35 min and was very much shorter than that of 3H-F. Concurrent with the disappearance of 3H-E was an increase in the amount of tritium in both the allantoic and the fetal blood compartments. Whereas following injection of 3H-E there was a rapid conversion of E to F that was reflected in all three compartments, following injection of 3H-F the vast majority of the tritium label remained as F. We conclude that amniotic E may act as a ready source of fetal F.
我们研究了在妊娠第25天向兔羊膜腔内注射[1,2 - ³H] - 可的松（³H - E）或[1,2,6,7 - n - ³H] - 皮质醇（³H - F）后放射性标记物的消失速率和形式。³H - E的半衰期约为35分钟，比³H - F的半衰期短得多。与³H - E的消失同时，尿囊和胎儿血液隔室中的氚含量增加。注射³H - E后，E迅速转化为F，这在所有三个隔室中都有体现；而注射³H - F后，绝大多数氚标记物仍为F。我们得出结论，羊膜腔内的E可能是胎儿F的现成来源。
