疾病标志物关联的通用模型。

A general model for disease-marker association.

作者信息

Risch N

出版信息

Ann Hum Genet. 1983 Jul;47(3):245-52. doi: 10.1111/j.1469-1809.1983.tb00992.x.

DOI:10.1111/j.1469-1809.1983.tb00992.x

Abstract

A general model for analysing disease-marker associations from a random sample of patients and controls is given, assuming an arbitrary number of marker and disease susceptibility alleles. A method for testing the goodness-of-fit of various disease susceptibility models to the observed distribution of genotypes at the marker locus in patient and control samples is given. The method is demonstrated using a recently published data set on type I diabetes.

摘要

给出了一个用于从患者和对照的随机样本中分析疾病标志物关联的通用模型，假设存在任意数量的标志物和疾病易感等位基因。给出了一种检验各种疾病易感性模型与患者和对照样本中标志物位点观察到的基因型分布拟合优度的方法。使用最近发表的关于1型糖尿病的数据集对该方法进行了演示。