HLA phenotype and haplotype frequencies in a sample of the Spanish population.

The frequencies of HLA antigens and genes were determined in 491 unrelated individuals from the area of Madrid. In order to obtain a fairly good idea of the HLA antigen frequencies in the Spanish population, our results have been compared with those reported from Barcelona. Haplotype frequencies were observed in 212 parents and compared with the frequencies estimated from the 491 individuals. The present data show certain characteristics of the Spanish population and are in good agreement with other studies in the demonstration of linkage disequilibrium between genes of the two series.