关于两个新的HLA - D决定簇EI和RE的群体数据。

Population data on two new HLA-D determinants, EI and RE.

作者信息

Grosse-Wilde H, Hauptmann G, Johannsen R, Netzel B, Rittner C, Ruppelt W

出版信息

Scand J Immunol. 1977;6(5):515-21. doi: 10.1111/j.1365-3083.1977.tb02114.x.

DOI:10.1111/j.1365-3083.1977.tb02114.x

Abstract

Homozygous typing cells (HTC) for two new HLA-D determinants, EI and RE, defined by family studies, are described. The HLA-D typing experiments among more than 300 unrelated individuals showed phenotype frequencies of 0.045 for EI and 0.098 for RE. Since the tested population was also typed for its HLA-A and -B alleles, linkage disequilibrium parameters could be calculated: HLA-D type EI was statistically significantly associated with HLA-B13 and Bw17, HLA-D type RE with HLA-Bw40. These data support the working hypothesis that both EI and RE are new alleles of the HLA-D series.

摘要

本文描述了通过家系研究确定的两个新的HLA - D决定簇EI和RE的纯合分型细胞（HTC）。在300多名无关个体中进行的HLA - D分型实验显示，EI的表型频率为0.045，RE的表型频率为0.098。由于对受试人群也进行了HLA - A和 - B等位基因分型，因此可以计算连锁不平衡参数：HLA - D型EI与HLA - B13和Bw17有统计学显著关联，HLA - D型RE与HLA - Bw40有统计学显著关联。这些数据支持了EI和RE都是HLA - D系列新等位基因的工作假设。