Costello P B, Brecher M L, Starr J I, Freeman A I, Green F A
J Rheumatol. 1983 Oct;10(5):753-7.
During a 2-year prospective study of 28 leukemic children (24, acute lymphocytic leukemia [ALL]; 4, non-ALL) unselected for musculoskeletal symptoms, objective joint findings were present in 14 cases (p = 0.001 vs normal controls). These findings varied in severity, were most frequently present in the knee (12 of 14 children), and were found most frequently only at disease onset (7 of 14). The group with joint abnormalities had a higher frequency of functionally significant joint complaints prior to diagnosis of leukemia (p = less than 0.01) and radiographic abnormalities of periarticular bone of the knees and ankles (p = less than 0.10). Four of the 5 children with ALL who died had joint findings, a trend whose significance is uncertain because of unequal followup periods.
在一项针对28名未因肌肉骨骼症状而被挑选的白血病儿童（24例急性淋巴细胞白血病[ALL]；4例非ALL）的为期2年的前瞻性研究中，14例出现了客观的关节检查结果（与正常对照组相比，p = 0.001）。这些结果严重程度各异，最常出现在膝关节（14名儿童中有12名），且最常在疾病发作时出现（14名中有7名）。有关节异常的组在白血病诊断前出现功能上显著的关节主诉的频率更高（p < 0.01），膝关节和踝关节周围骨骼的影像学异常也更多（p < 0.10）。5名死于ALL的儿童中有4名有关节检查结果，由于随访期不等，这一趋势的意义尚不确定。
