Croce C M, Thierfelder W, Erikson J, Nishikura K, Finan J, Lenoir G M, Nowell P C
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6922-6. doi: 10.1073/pnas.80.22.6922.
We have studied somatic cell hybrids between mouse myeloma cells and IARC-BL2 Burkitt lymphoma human cells carrying a t(8;22) chromosome translocation for the presence and expression of human immunoglobin lambda chains and for the c-myc oncogene. The results indicate that the c-myc oncogene remains on the 8q+ chromosome and that the excluded and rearranged C lambda allele translocates from chromosome 22 to this chromosome 8. As a result of the translocation, transcriptional activation of the c-myc oncogene on the rearranged chromosome 8 (8q+) occurs, while the c-myc oncogene in the normal chromosome 8 is transcriptionally silent. These findings suggest that the translocation of a rearranged immunoglobulin locus to the 3' side of an unrearranged c-myc oncogene may enhance its transcription and contribute to malignant transformation.
我们研究了小鼠骨髓瘤细胞与携带t(8;22)染色体易位的IARC-BL2伯基特淋巴瘤人类细胞之间的体细胞杂种，以检测人类免疫球蛋白λ链的存在和表达以及c-myc癌基因。结果表明，c-myc癌基因保留在8q+染色体上，被排除和重排的Cλ等位基因从22号染色体易位到该8号染色体。由于易位，重排的8号染色体（8q+）上的c-myc癌基因发生转录激活，而正常8号染色体上的c-myc癌基因转录沉默。这些发现表明，重排的免疫球蛋白基因座易位到未重排的c-myc癌基因的3'端可能会增强其转录并促进恶性转化。
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