Hudson J I, Pope H G, Jonas J M, Yurgelun-Todd D
Psychiatry Res. 1983 Aug;9(4):345-54. doi: 10.1016/0165-1781(83)90008-2.
We administered the National Institute of Mental Health Diagnostic Interview Schedule to 41 patients with a lifetime history of anorexia nervosa (25 with and 16 without bulimia) and to 49 patients with bulimia alone. Results showed that 77% of the patients with eating disorders had a lifetime diagnosis of DSM-III major affective disorder, a rate significantly higher than that found in comparison groups composed of the first-degree relatives of probands with schizophrenia and bipolar disorder. High lifetime rates of anxiety disorders, substance use disorders, and kleptomania were also observed. By contrast, few cases of personality disorders and no cases of schizophrenia were found. These findings combine with the results of studies of family history, long-term outcome, response to biological tests, and treatment response to suggest that anorexia nervosa and bulimia may be closely related to major affective disorder.
我们对41例有神经性厌食症终生病史的患者（25例伴有贪食症，16例不伴有贪食症）以及49例仅有贪食症的患者进行了美国国立精神卫生研究所诊断访谈表调查。结果显示，77%的饮食失调患者被诊断为终生患有DSM-III重度情感障碍，这一比例显著高于由精神分裂症和双相情感障碍先证者的一级亲属组成的对照组。还观察到焦虑症、物质使用障碍和偷窃癖的终生患病率较高。相比之下，发现人格障碍的病例很少，且未发现精神分裂症病例。这些发现与家族史、长期预后、生物学测试反应和治疗反应的研究结果相结合，表明神经性厌食症和贪食症可能与重度情感障碍密切相关。
