[Cerebral cortical neuron tolerance to the repeated administration of diazepam].

The depressive action of intravenously injected diazepam on the spontaneous electric activity of the sensomotor cortex neurons was studied in acute tests on rabbits. After introduction of 1 mg/kg of the drug an acute tolerance of a repeat introduction of it in the same dose developing 40--60 min following the first injection was observed. Earlier after the first injection (up to 20--40 min) the tolerance was lacking. It is suggested that the tolerance of a repeat introduction of diazepam is due to a concurrent blocking of the nervous tissue receptors sensitive to diazepam by the products of its (diazepam) metabolism.