Dole V P, Gentry R T
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3543-6. doi: 10.1073/pnas.81.11.3543.
Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since the drinking lacks serious toxic effects and the intoxication occurs only as transient episodes in association with homeostatic consumption of fluid and food. It is suggested that continuous monitoring of intake and estimation of the concentration of alcohol in blood, which are now technically feasible, will permit distinction between alcoholic-type drinking and a simple licking for the flavor of alcohol in beverage concentration.
给C57BL品系的小鼠持续提供10%的酒精和普通水，食物不限且无压力，它们经常会饮用足够的酒精，使血液中的酒精达到中毒水平。然而，这种行为似乎并未重现人类酗酒的基本特征，因为这种饮酒行为没有严重的毒性作用，而且中毒仅作为与液体和食物的稳态消耗相关的短暂发作出现。有人提出，目前在技术上可行的对摄入量的持续监测和血液中酒精浓度的估计，将有助于区分酒精性饮酒和单纯为了饮料浓度中的酒精味道而舔舐的行为。
