迈向小鼠酒精中毒的类似物：模型中的比例因子。
Toward an analogue of alcoholism in mice: scale factors in the model.
作者信息
Dole V P, Gentry R T
出版信息
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3543-6. doi: 10.1073/pnas.81.11.3543.
Abstract
Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since the drinking lacks serious toxic effects and the intoxication occurs only as transient episodes in association with homeostatic consumption of fluid and food. It is suggested that continuous monitoring of intake and estimation of the concentration of alcohol in blood, which are now technically feasible, will permit distinction between alcoholic-type drinking and a simple licking for the flavor of alcohol in beverage concentration.
摘要
给C57BL品系的小鼠持续提供10%的酒精和普通水，食物不限且无压力，它们经常会饮用足够的酒精，使血液中的酒精达到中毒水平。然而，这种行为似乎并未重现人类酗酒的基本特征，因为这种饮酒行为没有严重的毒性作用，而且中毒仅作为与液体和食物的稳态消耗相关的短暂发作出现。有人提出，目前在技术上可行的对摄入量的持续监测和血液中酒精浓度的估计，将有助于区分酒精性饮酒和单纯为了饮料浓度中的酒精味道而舔舐的行为。
相似文献
1
Toward an analogue of alcoholism in mice: scale factors in the model.迈向小鼠酒精中毒的类似物：模型中的比例因子。
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3543-6. doi: 10.1073/pnas.81.11.3543.
2
Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice.对C57BL/6J小鼠乙醇摄入致中毒的简单模型的评估。
Physiol Behav. 2005 Jan 31;84(1):53-63. doi: 10.1016/j.physbeh.2004.10.007.
3
Toward an analogue of alcoholism in mice: criteria for recognition of pharmacologically motivated drinking.迈向小鼠酒精中毒的类似物：药理学驱动饮酒的识别标准。
Proc Natl Acad Sci U S A. 1985 May;82(10):3469-71. doi: 10.1073/pnas.82.10.3469.
4
An experimental model of self-intoxication in C57 mice.C57小鼠自身中毒的实验模型
Alcohol. 1985 Sep-Oct;2(5):671-5. doi: 10.1016/0741-8329(85)90145-4.
5
Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice.阿坎酸和MPEP对雄性C57BL/6J小鼠黑暗中饮酒的急性影响。
Alcohol Clin Exp Res. 2008 Nov;32(11):1992-8. doi: 10.1111/j.1530-0277.2008.00787.x. Epub 2008 Sep 6.
6
Accumbens neurochemical adaptations produced by binge-like alcohol consumption.暴饮式饮酒产生的伏隔核神经化学适应性变化。
Psychopharmacology (Berl). 2007 Mar;190(4):415-31. doi: 10.1007/s00213-006-0641-7. Epub 2007 Jan 16.
7
Gender and age at drinking onset affect voluntary alcohol consumption but neither the alcohol deprivation effect nor the response to stress in mice.饮酒起始时的性别和年龄会影响小鼠的自愿酒精摄入量，但对酒精剥夺效应和应激反应均无影响。
Alcohol Clin Exp Res. 2008 Dec;32(12):2100-6. doi: 10.1111/j.1530-0277.2008.00798.x. Epub 2008 Sep 25.
8
A procedure to produce high alcohol intake in mice.一种使小鼠产生高酒精摄入量的方法。
Psychopharmacology (Berl). 2005 Apr;178(4):471-80. doi: 10.1007/s00213-004-2039-8. Epub 2004 Nov 3.
9
Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats.大鼠持续胃内输注乙醇期间血液酒精水平的周期性模式。
Alcohol Clin Exp Res. 1985 Jan-Feb;9(1):31-7. doi: 10.1111/j.1530-0277.1985.tb05046.x.
10
Mouse inbred strain differences in ethanol drinking to intoxication.近交系小鼠在饮酒致醉方面的差异。
Genes Brain Behav. 2007 Feb;6(1):1-18. doi: 10.1111/j.1601-183X.2006.00210.x.
引用本文的文献
1
Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA.化学遗传抑制蓝斑至中脑腹侧被盖区去甲肾上腺素能通路增加雄性和雌性小鼠光周期乙醇摄入，并减弱乙醇诱导的条件性位置偏爱。
Neuropharmacology. 2024 Feb 15;244:109809. doi: 10.1016/j.neuropharm.2023.109809. Epub 2023 Dec 3.
2
Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.乙醛和错配修复缺陷增加 Aldh1b1 失活的林奇综合征模型中的结肠肿瘤。
Dis Model Mech. 2023 Aug 1;16(8). doi: 10.1242/dmm.050240. Epub 2023 Jul 31.
3
Independent of differences in taste, B6N mice consume less alcohol than genetically similar B6J mice, and exhibit opposite polarity modulation of tonic GABAR currents by alcohol.与味觉差异无关，B6N小鼠比基因相似的B6J小鼠摄入的酒精更少，并且酒精对其强直型GABAR电流表现出相反的极性调节。
Neuropharmacology. 2022 Mar 15;206:108934. doi: 10.1016/j.neuropharm.2021.108934. Epub 2021 Dec 20.
4
Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome.乙醇诱导林奇综合征小鼠模型结直肠肿瘤和前体的形成。
J Pathol. 2021 Dec;255(4):464-474. doi: 10.1002/path.5796. Epub 2021 Oct 13.
5
Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function.高脂饮食和乙醇摄入对调节情绪处理和代谢功能的神经回路的影响。
Front Behav Neurosci. 2021 Jan 26;14:601111. doi: 10.3389/fnbeh.2020.601111. eCollection 2020.
6
Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication.为致醉而选择性培育的小鼠品系中的乙醇相关行为。
Brain Sci. 2021 Feb 4;11(2):189. doi: 10.3390/brainsci11020189.
7
Growth Factors and Alcohol Use Disorder.生长因子与酒精使用障碍
Cold Spring Harb Perspect Med. 2020 Dec 1;10(12):a039271. doi: 10.1101/cshperspect.a039271.
8
Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice.黑暗中高饮量小鼠的乙醇条件性味觉厌恶
Brain Sci. 2019 Jan 1;9(1):2. doi: 10.3390/brainsci9010002.
9
Calcium/calmodulin-stimulated adenylyl cyclases 1 and 8 regulate reward-related brain activity and ethanol consumption.钙/钙调蛋白激活的腺苷酸环化酶 1 和 8 调节与奖赏相关的大脑活动和乙醇消耗。
Brain Imaging Behav. 2019 Apr;13(2):396-407. doi: 10.1007/s11682-018-9856-6.
10
Concomitant Caffeine Increases Binge Consumption of Ethanol in Adolescent and Adult Mice, But Produces Additive Motor Stimulation Only in Adolescent Animals.同时摄入咖啡因会增加青少年和成年小鼠的乙醇暴饮，但仅在青少年动物中产生累加性运动刺激。
Alcohol Clin Exp Res. 2016 Jun;40(6):1351-60. doi: 10.1111/acer.13089. Epub 2016 May 7.
本文引用的文献
1
Adaptation of orbital bleeding technic to rapid serial blood studies.眼眶出血技术在快速系列血液研究中的应用。
Proc Soc Exp Biol Med. 1960 Aug-Sep;104:751-4. doi: 10.3181/00379727-104-25975.
2
Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats.
Pharmacol Biochem Behav. 1982 Jan;16(1):125-30. doi: 10.1016/0091-3057(82)90023-5.
3
Pharmacokinetics of ethanol: a review.
Alcohol Clin Exp Res. 1980 Jan;4(1):6-21. doi: 10.1111/j.1530-0277.1980.tb04785.x.
4
Serial determination of plasma ethanol concentrations in mice.小鼠血浆乙醇浓度的系列测定
Physiol Behav. 1983 Oct;31(4):529-32. doi: 10.1016/0031-9384(83)90077-x.
5
An improved technique for monitoring the drinking behavior of mice.
Physiol Behav. 1983 Jun;30(6):971-4. doi: 10.1016/0031-9384(83)90264-0.
6
Elevated concentrations of ethanol in plasma do not suppress voluntary ethanol consumption in C57BL mice.
Alcohol Clin Exp Res. 1983 Fall;7(4):420-3. doi: 10.1111/j.1530-0277.1983.tb05498.x.
7
Alcohol withdrawal syndrome in mice.
Arch Neurol. 1969 Sep;21(3):315-20. doi: 10.1001/archneur.1969.00480150105013.
8
Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction.通过吸入乙醇在小鼠中产生酒精依赖：对戒断反应进行分级
Science. 1971 Apr 16;172(3980):288-90. doi: 10.1126/science.172.3980.288.
9
Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat.
Science. 1972 Sep 1;177(4051):811-3. doi: 10.1126/science.177.4051.811.
10
Evaluation of a polydipsia technique to induce alcohol consumption in monkeys.
Physiol Behav. 1971 Dec;7(6):827-36. doi: 10.1016/0031-9384(71)90047-3.
Zotero 插件