Dole V P, Ho A, Gentry R T
Proc Natl Acad Sci U S A. 1985 May;82(10):3469-71. doi: 10.1073/pnas.82.10.3469.
Two criteria of alcoholic drinking behavior--inelasticity of demand and dissociation of intake from normal eating and drinking--are illustrated by study of alcohol-preferring C57BL/6J mice. Although these mice drink enough to become intoxicated for brief periods each night, they do not meet the more rigorous criteria for pharmacologically motivated drinking. Their intake of alcohol was dramatically decreased when they were offered diets augmented with sugar or Crisco, and the temporal pattern of drinking was correlated with the intake of food. Thus, their motivation for drinking alcohol is related to nutrition and is not drug-seeking comparable to that of human alcoholics. Since the tests are simple and decisive, it might be useful to apply them to all putative models of alcoholism.
通过对偏爱酒精的C57BL/6J小鼠的研究，阐述了酒精饮用行为的两个标准——需求无弹性以及饮酒与正常饮食的分离。尽管这些小鼠每晚饮用足够多的酒以至于会在短时间内中毒，但它们并不符合药理学驱动饮酒的更严格标准。当给它们提供添加了糖或起酥油的食物时，它们的酒精摄入量显著减少，并且饮酒的时间模式与食物摄入量相关。因此，它们饮酒的动机与营养有关，并非像人类酗酒者那样寻求药物。由于这些测试简单且具有决定性，将其应用于所有假定的酒精中毒模型可能会很有用。
