Köhler B, Andréen I, Jonsson B
Arch Oral Biol. 1984;29(11):879-83. doi: 10.1016/0003-9969(84)90086-4.
Seventy-seven first-time mothers were selected on the basis of high salivary counts of Strep. mutans [greater than 10(6) c.f.u. (colony forming units) per ml saliva]; 40 mothers were in the control group and 37 in the test group. Their infants were 3-8 months of age at the start of the study. A prophylactic programme for the test mothers, aiming at a reduction of Strep. mutans, was repeated at intervals of 2-4 months as and when necessary until their children were 3 years old. The test mothers as a group showed approx. 10-fold fewer Strep. mutans during the test period. At the age of 3 years, 70 per cent of the children in the control group carried Strep. mutans, compared with 41 per cent in the test group (p less than 0.01). Fifty-two per cent of the children who carried Strep. mutans had caries at this age, compared to 3 per cent of the children without this organism. The time when Strep. mutans was first detected in the children seemed to influence subsequent development of caries because 77 per cent of the children who carried Strep. mutans at the age of 15 months had caries at the age of 3 years. Approximately 40 per cent of the children in both the control and the test group had detectable lactobacilli in their saliva at 3 years. In general, the children in the control group had more lactobacilli.(ABSTRACT TRUNCATED AT 250 WORDS)
77名初产妇因唾液中变形链球菌计数较高（每毫升唾液大于10⁶ c.f.u.（菌落形成单位））而被选中；40名母亲为对照组，37名母亲为试验组。研究开始时，她们的婴儿年龄在3至8个月之间。针对试验组母亲的一项预防性方案旨在减少变形链球菌，必要时每2至4个月重复一次，直至其孩子3岁。试验组母亲作为一个整体在试验期间的变形链球菌数量约少10倍。在3岁时，对照组70%的儿童携带变形链球菌，而试验组为41%（p<0.01）。携带变形链球菌的儿童中，52%在这个年龄患有龋齿，而未携带该菌的儿童中这一比例为3%。儿童首次检测到变形链球菌的时间似乎会影响随后龋齿的发展，因为15个月时携带变形链球菌的儿童中，77%在3岁时患有龋齿。对照组和试验组中约40%的儿童在3岁时唾液中可检测到乳酸杆菌。总体而言，对照组的儿童乳酸杆菌更多。（摘要截选至250字）
