Sanson-Le Pors M J, Casin I, Ortenberg M, Perol Y
J Antimicrob Chemother. 1983 Mar;11(3):271-80. doi: 10.1093/jac/11.3.271.
We have studied the in-vitro susceptibility of 30 strains of Haemophilus ducreyi to 22 antibacterial agents. Twenty-seven strains produced a beta-lactamase that had an isoelectric point similar to the isoelectric point of the TEM 1 type beta-lactamase produced by pSF 2124. Except for cefamandole, the 30 strains had similar susceptibilities to the different cephalosporins, cefotaxime being the most active compound. Twenty-two isolates were resistant to tetracycline and doxycycline; minimal inhibitory concentration (MIC) of minocycline was 4 mg/l for all the strains. One isolate was resistant to chloramphenicol (MIC = 16 mg/l). All strains were relatively resistant to colistin and nalidixic acid, and susceptible to streptomycin, kanamycin, gentamicin, erythromycin, rifampicin and vancomycin.
我们研究了30株杜克雷嗜血杆菌对22种抗菌剂的体外敏感性。27株菌株产生了一种β-内酰胺酶，其等电点与由pSF 2124产生的TEM 1型β-内酰胺酶的等电点相似。除头孢孟多外，这30株菌株对不同头孢菌素的敏感性相似，头孢噻肟是最具活性的化合物。22株分离株对四环素和强力霉素耐药；所有菌株对米诺环素的最低抑菌浓度（MIC）为4mg/l。1株分离株对氯霉素耐药（MIC = 16mg/l）。所有菌株对黏菌素和萘啶酸相对耐药，对链霉素、卡那霉素、庆大霉素、红霉素、利福平和万古霉素敏感。
