McQuillen D P, Koethe S M, McQuillen M P
J Neuroimmunol. 1983 Aug;5(1):59-65. doi: 10.1016/0165-5728(83)90026-7.
A preparation of human skeletal muscle acetylcholine receptor (AchR) was used in vitro as an antigen to stimulate lymphocytes from patients with myasthenia gravis (MG). Clinical data obtained from the patients included duration and severity of disease; history of steroid treatment or prior thymectomy; and the presence of thymoma. Lymphocytes from patients with MG showed a significantly higher response to human AchR antigen than did lymphocytes from control subjects. Previous studies of cellular response to AchR have used receptor prepared from eel or ray electric organs. By stimulating lymphocytes from MG patients with a preparation of human AchR, we have come one step closer to documenting a possible contribution of a cellular immune response to the pathogenesis of MG.
将人体骨骼肌乙酰胆碱受体（AchR）制剂在体外用作抗原，以刺激重症肌无力（MG）患者的淋巴细胞。从患者获得的临床数据包括疾病持续时间和严重程度；类固醇治疗史或先前的胸腺切除术史；以及胸腺瘤的存在情况。MG患者的淋巴细胞对人AchR抗原的反应明显高于对照受试者的淋巴细胞。先前关于细胞对AchR反应的研究使用的是从鳗鱼或鳐鱼电器官制备的受体。通过用人AchR制剂刺激MG患者的淋巴细胞，我们在证明细胞免疫反应对MG发病机制的可能作用方面又迈进了一步。
