表皮生长因子对离体大鼠肝细胞中磷脂甲基转移酶的刺激作用。

Stimulation by epidermal growth factor of phospholipid methyltransferase in isolated rat hepatocytes.

作者信息

Chiva V A, Cao D M, Mato J M

出版信息

FEBS Lett. 1983 Aug 22;160(1-2):101-4. doi: 10.1016/0014-5793(83)80945-4.

Abstract

Epidermal growth factor produces a time- and dose-dependent activation of phospholipid methyltransferase activity in hepatocytes isolated from juvenile and mature hepatectomized rats. This treatment however has no effect with hepatocytes isolated from mature or laparotomized rats. Dansylcadaverine (50 microM), an inhibitor of receptor-mediated internalization of epidermal growth factor, has no effect on basal phospholipid methyltransferase but inhibits the stimulation of this enzyme by epidermal growth factor. These results indicate a possible role of phospholipid methylation during liver proliferation.

摘要

表皮生长因子对从幼年和成年肝切除大鼠分离的肝细胞中的磷脂甲基转移酶活性产生时间和剂量依赖性激活。然而，这种处理对从成年或剖腹大鼠分离的肝细胞没有影响。丹磺酰尸胺（50微摩尔），一种表皮生长因子受体介导的内化抑制剂，对基础磷脂甲基转移酶没有影响，但抑制表皮生长因子对该酶的刺激作用。这些结果表明磷脂甲基化在肝脏增殖过程中可能发挥作用。