由需要胸苷、对甲氧苄啶耐药的细菌引起的感染。
Infection caused by thymidine-requiring, trimethoprim-resistant bacteria.
作者信息
King C H, Shlaes D M, Dul M J
出版信息
J Clin Microbiol. 1983 Jul;18(1):79-83. doi: 10.1128/jcm.18.1.79-83.1983.
Abstract
We first noted the appearance of thymidine-requiring, gram-negative bacilli in clinical specimens 2 years ago. Since then we have seen 10 patients colonized or infected with these organisms. These strains do not grow on Mueller-Hinton media, growth on MacConkey agar is variable, and growth in API 20E (Analytab Products) and Enterobacteriaceae-Plus Cards (AutoMicrobic system; Vitek Systems Inc.) is inadequate for reliable identifications. Thymidine-requiring organisms are routinely resistant to sulfonamides and trimethoprim. Infection or colonization is associated with previous sulfamethoxazole-trimethoprim therapy in most cases. Of 10 patients, 1 had septicemia of urinary tract origin, 5 had urinary tract colonization or infection, 2 had wound colonization, and two had colonization of respiratory secretions. Thymidine-requiring, gram-negative bacilli can be pathogens and present potential problems in diagnosis, identification, and susceptibility testing.
摘要
两年前我们首次在临床标本中注意到需要胸苷的革兰氏阴性杆菌。从那时起，我们已经发现10例患者被这些微生物定植或感染。这些菌株在穆勒-欣顿培养基上不生长，在麦康凯琼脂上的生长情况不一，在API 20E（Analytab Products公司）和肠杆菌科加卡片（自动微生物系统；Vitek系统公司）中生长不足以进行可靠鉴定。需要胸苷的微生物通常对磺胺类药物和甲氧苄啶耐药。在大多数情况下，感染或定植与先前的磺胺甲恶唑-甲氧苄啶治疗有关。10例患者中，1例有尿路感染引起的败血症，5例有尿道定植或感染，2例有伤口定植，2例有呼吸道分泌物定植。需要胸苷的革兰氏阴性杆菌可能是病原体，在诊断、鉴定和药敏试验中存在潜在问题。
相似文献
1
Infection caused by thymidine-requiring, trimethoprim-resistant bacteria.由需要胸苷、对甲氧苄啶耐药的细菌引起的感染。
J Clin Microbiol. 1983 Jul;18(1):79-83. doi: 10.1128/jcm.18.1.79-83.1983.
2
Comparison of a novel trimethoprim-sulfamethoxazole-containing medium (XT80) with kanamycin agar for isolation of antibiotic-resistant organisms from stool and rectal cultures of marrow transplant patients.一种含新型甲氧苄啶-磺胺甲恶唑的培养基（XT80）与卡那霉素琼脂用于从骨髓移植患者粪便和直肠培养物中分离耐药菌的比较。
J Clin Microbiol. 1987 Oct;25(10):1886-90. doi: 10.1128/jcm.25.10.1886-1890.1987.
3
Co-trimoxazole susceptibility tests improved with separate trimethoprim and sulfamethoxazole disks.使用单独的甲氧苄啶和磺胺甲恶唑药敏纸片可提高复方新诺明药敏试验的效果。
J Clin Microbiol. 1981 Apr;13(4):613-7. doi: 10.1128/jcm.13.4.613-617.1981.
4
Effect of changing selection pressures on trimethoprim resistance in Enterobacteriaceae.选择压力变化对肠杆菌科细菌甲氧苄啶耐药性的影响。
Eur J Clin Microbiol. 1986 Oct;5(5):502-6. doi: 10.1007/BF02017691.
5
Co-trimoxazole resistance in Jamaica.牙买加的复方新诺明耐药性。
Lancet. 1986 Apr 19;1(8486):923. doi: 10.1016/s0140-6736(86)91033-0.
6
Incidence of trimethoprim-sulfamethoxazole-resistant enterobacteriaceae among transplant recipients.移植受者中对甲氧苄啶-磺胺甲恶唑耐药的肠杆菌科细菌的发生率。
J Infect Dis. 1984 Nov;150(5):699-706. doi: 10.1093/infdis/150.5.699.
7
Effect of minimal amounts of thymidine on activity of trimethoprim-sulfamethoxazole against Staphylococcus epidermidis.微量胸苷对甲氧苄啶-磺胺甲恶唑抗表皮葡萄球菌活性的影响
Antimicrob Agents Chemother. 1987 Feb;31(2):144-7. doi: 10.1128/AAC.31.2.144.
8
In vitro activity of cefixime and six other agents against nosocomial pathogens of the Enterobacteriaceae family.头孢克肟及其他六种药物对肠杆菌科医院病原体的体外活性。
Infect Control. 1987 Jun;8(6):241-4. doi: 10.1017/s019594170006611x.
9
Trimethoprim-resistant Enterobacteriaceae in urinary tract infection.尿路感染中对甲氧苄啶耐药的肠杆菌科细菌
Can Med Assoc J. 1975 Jun 14;112(13 Spec No):54-8.
10
Spurious sulfamethoxazole-trimethoprim resistance of Salmonella typhi.伤寒沙门菌对磺胺甲恶唑-甲氧苄啶的假性耐药
J Clin Microbiol. 1986 Jan;23(1):205-6. doi: 10.1128/jcm.23.1.205-206.1986.
引用本文的文献
1
Considering Metabolic Context in Enzyme Evolution and Design.酶进化与设计中的代谢背景考量
Biochemistry. 2025 Aug 19;64(16):3495-3507. doi: 10.1021/acs.biochem.5c00165. Epub 2025 Aug 5.
2
The genetic landscape of a metabolic interaction.代谢相互作用的遗传全景
Nat Commun. 2024 Apr 18;15(1):3351. doi: 10.1038/s41467-024-47671-0.
3
Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race.抗生素与细菌耐药性——一场无休止军备竞赛的简史。
Int J Mol Sci. 2023 Mar 17;24(6):5777. doi: 10.3390/ijms24065777.
4
Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection.从反复发生血流感染的患者中分离的大肠杆菌中胸腺嘧啶营养缺陷型的表型和基因型特征。
PLoS One. 2022 Jul 8;17(7):e0270256. doi: 10.1371/journal.pone.0270256. eCollection 2022.
5
Evolutionary Repair Experiments as a Window to the Molecular Diversity of Life.进化修复实验：窥探生命分子多样性的窗口。
Curr Biol. 2020 May 18;30(10):R565-R574. doi: 10.1016/j.cub.2020.03.046.
6
High-level resistance to trimethoprim in clinical isolates of Campylobacter jejuni by acquisition of foreign genes (dfr1 and dfr9) expressing drug-insensitive dihydrofolate reductases.空肠弯曲菌临床分离株通过获得表达对药物不敏感的二氢叶酸还原酶的外源基因（dfr1和dfr9）而对甲氧苄啶产生高水平耐药。
Antimicrob Agents Chemother. 1998 Dec;42(12):3059-64. doi: 10.1128/AAC.42.12.3059.
7
Trimethoprim and sulfonamide resistance.甲氧苄啶和磺胺耐药性。
Antimicrob Agents Chemother. 1995 Feb;39(2):279-89. doi: 10.1128/AAC.39.2.279.
8
Trimethoprim resistance.甲氧苄啶耐药性
Antimicrob Agents Chemother. 1987 Oct;31(10):1451-6. doi: 10.1128/AAC.31.10.1451.
9
Comparison of a novel trimethoprim-sulfamethoxazole-containing medium (XT80) with kanamycin agar for isolation of antibiotic-resistant organisms from stool and rectal cultures of marrow transplant patients.一种含新型甲氧苄啶-磺胺甲恶唑的培养基（XT80）与卡那霉素琼脂用于从骨髓移植患者粪便和直肠培养物中分离耐药菌的比较。
J Clin Microbiol. 1987 Oct;25(10):1886-90. doi: 10.1128/jcm.25.10.1886-1890.1987.
本文引用的文献
1
IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI.改进的大肠杆菌胸腺嘧啶需求突变体分离方法。
J Bacteriol. 1965 Aug;90(2):554-5. doi: 10.1128/jb.90.2.554-555.1965.
2
Increasing importance of plasmid-mediated trimethoprim resistance in enterobacteria: two six-month clinical surveys.质粒介导的甲氧苄啶耐药性在肠杆菌中日益重要：两项为期六个月的临床调查
Br Med J. 1980 Feb 23;280(6213):517-9. doi: 10.1136/bmj.280.6213.517.
3
Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole.对甲氧苄啶、磺胺类药物及复方新诺明的耐药机制
Rev Infect Dis. 1982 Mar-Apr;4(2):261-9. doi: 10.1093/clinids/4.2.261.
4
A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia.甲氧苄啶-磺胺甲恶唑联合制霉菌素与庆大霉素联合制霉菌素预防急性白血病感染的比较
N Engl J Med. 1981 Apr 30;304(18):1057-62. doi: 10.1056/NEJM198104303041801.
5
Incidence of thymidine-dependent enterococci detected on Mueller-Hinton agar with low thymidine content.在低胸苷含量的穆勒-欣顿琼脂上检测到的胸苷依赖性肠球菌的发生率。
Antimicrob Agents Chemother. 1980 Sep;18(3):365-8. doi: 10.1128/AAC.18.3.365.
6
Transposons and trimethoprim resistance.转座子与甲氧苄啶耐药性
Br Med J (Clin Res Ed). 1981 Apr 4;282(6270):1118-9. doi: 10.1136/bmj.282.6270.1118-a.
7
Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
Am J Clin Pathol. 1966 Apr;45(4):493-6.
8
Reversal of the antimicrobial activity of trimethoprim by thymidine in commercially prepared media.在商业制备的培养基中，胸腺嘧啶核苷可逆转甲氧苄啶的抗菌活性。
Appl Microbiol. 1971 Nov;22(5):812-7. doi: 10.1128/am.22.5.812-817.1971.
9
Letter: Is co-trimoxazole bactericidal in sputum?信件：复方新诺明在痰液中具有杀菌作用吗？
Br Med J. 1973 Oct 20;4(5885):165. doi: 10.1136/bmj.4.5885.165-b.
10
Use of trimethoprim to obtain thymine-requiring mutants of Streptococcus faecalis.使用甲氧苄啶获得粪肠球菌的胸腺嘧啶需求型突变体。
J Gen Microbiol. 1973 Jan;74(1):195-9. doi: 10.1099/00221287-74-1-195.
Zotero 插件