Mitsuya H, Matis L A, Megson M, Bunn P A, Murray C, Mann D L, Gallo R C, Broder S
J Exp Med. 1983 Sep 1;158(3):994-9. doi: 10.1084/jem.158.3.994.
Lymphocytes from a patient who had an unusually long survival after therapy for a human T cell leukemia/lymphoma virus (HTLV)-associated T cell lymphoma were stimulated in vitro with an autologous tumor cell line, and the generation of cytotoxic T lymphocytes (CTL) was studied. CTL generated were directed against autologous (HTLV-associated tumor cells. These propagated CTL were OKT3+, OKT4-, and OKT8+. The cytotoxic activity required target tumor cells that were infected with HTLV and also expressed histocompatibility antigens in common with the patient, suggesting a major histocompatibility complex-restricted associative recognition of target antigens expressed on the tumor cell membrane.
从一名患有人类T细胞白血病/淋巴瘤病毒(HTLV)相关T细胞淋巴瘤且治疗后存活期异常长的患者身上获取淋巴细胞,用自体肿瘤细胞系在体外进行刺激,并研究细胞毒性T淋巴细胞(CTL)的生成。所生成的CTL针对自体(HTLV相关肿瘤细胞)。这些增殖的CTL为OKT3 +、OKT4 -和OKT8 +。细胞毒性活性需要感染了HTLV且还表达与患者共有的组织相容性抗原的靶肿瘤细胞,这表明对肿瘤细胞膜上表达的靶抗原存在主要组织相容性复合体限制的联合识别。