针对一名感染人类T细胞白血病/淋巴瘤病毒患者的培养肿瘤细胞产生的HLA限制性细胞毒性T细胞系。
Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.
作者信息
Mitsuya H, Matis L A, Megson M, Bunn P A, Murray C, Mann D L, Gallo R C, Broder S
出版信息
J Exp Med. 1983 Sep 1;158(3):994-9. doi: 10.1084/jem.158.3.994.
Abstract
Lymphocytes from a patient who had an unusually long survival after therapy for a human T cell leukemia/lymphoma virus (HTLV)-associated T cell lymphoma were stimulated in vitro with an autologous tumor cell line, and the generation of cytotoxic T lymphocytes (CTL) was studied. CTL generated were directed against autologous (HTLV-associated tumor cells. These propagated CTL were OKT3+, OKT4-, and OKT8+. The cytotoxic activity required target tumor cells that were infected with HTLV and also expressed histocompatibility antigens in common with the patient, suggesting a major histocompatibility complex-restricted associative recognition of target antigens expressed on the tumor cell membrane.
摘要
从一名患有人类T细胞白血病/淋巴瘤病毒（HTLV）相关T细胞淋巴瘤且治疗后存活期异常长的患者身上获取淋巴细胞，用自体肿瘤细胞系在体外进行刺激，并研究细胞毒性T淋巴细胞（CTL）的生成。所生成的CTL针对自体（HTLV相关肿瘤细胞）。这些增殖的CTL为OKT3 +、OKT4 -和OKT8 +。细胞毒性活性需要感染了HTLV且还表达与患者共有的组织相容性抗原的靶肿瘤细胞，这表明对肿瘤细胞膜上表达的靶抗原存在主要组织相容性复合体限制的联合识别。
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本文引用的文献
1
Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma.人类T细胞白血病-淋巴瘤病毒（HTLV）存在于一名皮肤T细胞淋巴瘤患者的T淋巴细胞而非B淋巴细胞中。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5680-3. doi: 10.1073/pnas.79.18.5680.
2
Regression of a disseminated syngeneic solid tumor by systemic transfer of lymphoid cells expanded in interleukin 2.通过白细胞介素-2扩增的淋巴细胞进行全身转移，使播散性同基因实体瘤消退。
J Exp Med. 1982 Aug 1;156(2):385-97. doi: 10.1084/jem.156.2.385.
3
Retrovirus lymphomagenesis: relationship of normal immune receptors to malignant cell proliferation.逆转录病毒致淋巴瘤作用：正常免疫受体与恶性细胞增殖的关系。
Curr Top Microbiol Immunol. 1982;98:103-12. doi: 10.1007/978-3-642-68369-5_8.
4
Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.用环磷酰胺进行化学免疫疗法并过继转移同基因Lyt-1+2-淋巴细胞根除播散性小鼠白血病
J Exp Med. 1981 Sep 1;154(3):952-63. doi: 10.1084/jem.154.3.952.
5
6
Possible immunological mechanisms in C-type viral leukemogenesis in mice.
Curr Top Microbiol Immunol. 1982;98:85-101. doi: 10.1007/978-3-642-68369-5_7.
7
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.从一名皮肤T细胞淋巴瘤患者的新鲜淋巴细胞和培养淋巴细胞中检测并分离C型逆转录病毒颗粒。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9. doi: 10.1073/pnas.77.12.7415.
8
Efficacy of cryopreserved spleen cells in murine tumor immunotherapy.
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9
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10
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