Good J T, King T E, Antony V B, Sahn S A
Chest. 1983 Dec;84(6):714-8. doi: 10.1378/chest.84.6.714.
Eighteen patients with lupus erythematosus (LE) and pleural effusions were evaluated. Fourteen patients had lupus pleuritis and four had pleural effusions of other etiologies. All patients were symptomatic, and the presenting signs and symptoms did not help distinguish between lupus pleuritis and pleural effusions of other causes. The presence of LE cells confirmed the diagnosis of lupus pleuritis in seven of eight patients. In 11 of 13 patients with lupus pleuritis, the pleural fluid antinuclear antibody (ANA) titer was greater than or equal to 1:160, and in nine of 13 patients with lupus pleuritis, the pleural fluid to serum (PF/S) ANA ratio was greater than or equal to 1. In the four patients with LE and a pleural effusion of another etiology, the pleural fluid ANA titer was negative in two and low titer in two (1:40, 1:80); the pleural fluid to serum ANA titer was always less than one. Of 67 patients with pleural effusions of other etiologies, the pleural fluid ANA was negative. The signs and symptoms of lupus pleuritis are nonspecific, however; the findings of LE cells in pleural fluid confirms the diagnosis and a high pleural fluid ANA titer (greater than or equal to 1:160) and a PF/S ANA ratio of greater than or equal to 1 strongly supports the diagnosis.
对18例患有红斑狼疮（LE）并伴有胸腔积液的患者进行了评估。14例患者患有狼疮性胸膜炎，4例患者有其他病因导致的胸腔积液。所有患者均有症状，其出现的体征和症状无助于区分狼疮性胸膜炎和其他原因导致的胸腔积液。在8例患者中的7例中，LE细胞的存在证实了狼疮性胸膜炎的诊断。在13例狼疮性胸膜炎患者中的11例中，胸水抗核抗体（ANA）滴度大于或等于1:160，在13例狼疮性胸膜炎患者中的9例中，胸水与血清（PF/S）ANA比值大于或等于1。在4例患有LE并伴有其他病因胸腔积液的患者中，2例胸水ANA滴度为阴性，2例为低滴度（1:40，1:80）；胸水与血清ANA滴度始终小于1。在67例其他病因导致胸腔积液的患者中，胸水ANA为阴性。然而，狼疮性胸膜炎的体征和症状是非特异性的；胸水中LE细胞的发现可确诊，高胸水ANA滴度（大于或等于1:160）和PF/S ANA比值大于或等于1强烈支持该诊断。
