用秋水仙碱涂抹肛门唇对鸡进行去囊法处理后的胸腺依赖性免疫功能。

Thymus-dependent immune functions in chickens bursectomized with colchicine applied to the anal lips.

作者信息

Romppanen T, Eskola J, Lassila O, Viljanen M K, Sorvari T E

出版信息

Dev Comp Immunol. 1983 Summer;7(3):525-34. doi: 10.1016/0145-305x(83)90037-x.

Abstract

Thymus-dependent immune functions were investigated in chickens bursectomized neonatally with colchicine solution given per anum. Antibody responses to thymus-dependent antigens sheep red blood cells (SRBC) and human gamma-globulin (HGG) were delayed, reaching the normal level after the third antigen stimulation. Also the mitogenic responses of peripheral blood lymphocytes were preserved, and no changes in the thymic morphology were found. In contrast, antibody responses to bursa-dependent antigen Brucella abortus were low and the switch of immunoglobulin isotypes from IgM to IgA and IgG was disturbed. It can be concluded that neonatal bursectomy with cloacal administration of colchicine does not significantly affect T cell functions, whereas B cell functions are partially deficient.

摘要

对新生时经肛门给予秋水仙碱溶液进行法氏囊切除的鸡的胸腺依赖性免疫功能进行了研究。对胸腺依赖性抗原绵羊红细胞（SRBC）和人γ球蛋白（HGG）的抗体反应延迟，在第三次抗原刺激后达到正常水平。外周血淋巴细胞的促有丝分裂反应也得以保留，且胸腺形态未发现变化。相比之下，对法氏囊依赖性抗原流产布鲁氏菌的抗体反应较低，免疫球蛋白同种型从IgM向IgA和IgG的转换受到干扰。可以得出结论：新生时经泄殖腔给予秋水仙碱进行法氏囊切除不会显著影响T细胞功能，而B细胞功能则部分存在缺陷。