Carroll A J, Crist W M, Parmley R T, Roper M, Cooper M D, Finley W H
Blood. 1984 Mar;63(3):721-4.
Chromosome banding studies on 60 children with acute lymphocytic leukemia (ALL), including "null," pre-B, B, and T cell phenotypes, were performed. In 4 of 17 patients with pre-B cell ALL, we noted a previously undescribed chromosome translocation, t(1;19)(q23;q13). This translocation was not found in patients with "null" cell, B cell, or T cell ALL. Since each patient with the 1;19 translocation experienced early treatment failure, t(1;19)(q23;q13) may mark a subgroup of patients with pre-B cell ALL who have an especially poor prognosis.
对60名急性淋巴细胞白血病（ALL）患儿进行了染色体显带研究，这些患儿包括“无”、前B、B和T细胞表型。在17例前B细胞ALL患者中的4例中，我们发现了一种以前未描述过的染色体易位，即t(1;19)(q23;q13)。在“无”细胞、B细胞或T细胞ALL患者中未发现这种易位。由于每例发生1;19易位的患者均早期治疗失败，t(1;19)(q23;q13)可能标志着预后特别差的前B细胞ALL患者亚组。
