Williams D L, Look A T, Melvin S L, Roberson P K, Dahl G, Flake T, Stass S
Cell. 1984 Jan;36(1):101-9. doi: 10.1016/0092-8674(84)90078-3.
Cytogenetic analysis of leukemic cells obtained at diagnosis from 122 patients with childhood acute lymphoblastic leukemia (ALL) disclosed chromosomal translocations in 36 cases. Two new nonrandom translocations were identified and found to be associated with specific immunophenotypes of the disease. The first, identified in 4 of 16 cases of T-cell ALL positive for sheep erythrocyte receptors (E+), involved the short arm (p) of chromosome 11 and the long arm (q) of chromosome 14 and was designated t(11;14) (p13;q13). The second, found in 7 of 23 cases with a pre-B-cell phenotype, involved the long arm of chromosome 1 and the short arm of chromosome 19; it was designated t(1;19) (q23;p13.3). A third abnormality involving a common breakpoint on chromosome 12 (band p 12) was also identified. These two new differentiation-specific translocations suggest a mechanism for aberrant expression of genes that influence lymphoid cell growth and development, as well as leukemogenesis.
对122例儿童急性淋巴细胞白血病（ALL）患者诊断时获取的白血病细胞进行细胞遗传学分析，发现36例存在染色体易位。鉴定出两种新的非随机易位，并发现它们与该疾病的特定免疫表型相关。第一种易位在16例对绵羊红细胞受体呈阳性（E+）的T细胞ALL中的4例中被鉴定出来，涉及11号染色体短臂（p）和14号染色体长臂（q），被命名为t(11;14)(p13;q13)。第二种易位在23例具有前B细胞表型的病例中的7例中被发现，涉及1号染色体长臂和19号染色体短臂；它被命名为t(1;19)(q23;p13.3)。还鉴定出第三种异常，涉及12号染色体上一个常见的断点（带p12）。这两种新的分化特异性易位提示了一种影响淋巴细胞生长发育以及白血病发生的基因异常表达机制。
