Ramon Y, Behar S, Kishon Y, Engelberg I S
Int J Cardiol. 1984 Feb;5(2):195-206. doi: 10.1016/0167-5273(84)90145-1.
We observed marked gingival hyperplasia, similar clinically and histologically to the hyperplasia caused by 5:5 sodium diphenylhydantoin (Dilantin) during the last 18 months in five patients treated by nifedipine. Histologically, marked epithelial hyperplasia-acanthosis, with moderate inflammatory reaction in the lamina propria, was observed in all the biopsy specimens. Evidence points to a strong relationship between the gingival hyperplasia and the administration of nifedipine.
在过去18个月中，我们观察到5例接受硝苯地平治疗的患者出现了明显的牙龈增生，其临床和组织学表现与5:5苯妥英钠（大仑丁）引起的增生相似。组织学上，在所有活检标本中均观察到明显的上皮增生——棘皮症，固有层有中度炎症反应。有证据表明牙龈增生与硝苯地平的使用之间存在密切关系。
