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钙通道阻滞剂引起的牙龈增生的治疗,无需改变药物治疗。

Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication.

机构信息

Department of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Department of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

出版信息

BMJ Case Rep. 2021 Jan 11;14(1):e238872. doi: 10.1136/bcr-2020-238872.

Abstract

Gingival overgrowth is a common side effect of calcium channel blockers used in the treatment of cardiovascular diseases. While controversial, management includes discontinuing the calcium channel blocker. We report the case of a 66-year-old Japanese man with hypertension and type 2 diabetes mellitus who was diagnosed with severe periodontitis covering almost all the teeth. The patient had been on nifedipine (40 mg/day) and amlodipine (10 mg/day) medication for 5 years. With his physician's consent, nifedipine was discontinued during his treatment for periodontitis, which consisted of oral hygiene instructions and scaling and root planing on all areas. Gingivectomy was performed on the areas of hard fibrous swelling. Nifedipine was resumed during periodontal treatment when the patient's hypertension worsened. His periodontal scores improved when he resumed treatment. We report that significant improvement in gingival overgrowth can occur with basic periodontal treatment, surgery and sustained intensive follow-up without adjusting calcium channel blockers.

摘要

牙龈增生是心血管疾病治疗中使用的钙通道阻滞剂的常见副作用。虽然存在争议,但管理方法包括停用钙通道阻滞剂。我们报告了一例 66 岁的日本男性,患有高血压和 2 型糖尿病,被诊断患有几乎覆盖所有牙齿的严重牙周炎。该患者服用硝苯地平(40mg/天)和氨氯地平(10mg/天)药物已有 5 年。在牙周炎治疗期间,经医生同意停用硝苯地平,治疗包括口腔卫生指导和所有部位的洁治和根面平整。对硬纤维性肿胀区域行牙龈切除术。当患者的高血压加重时,在牙周病治疗期间重新开始使用硝苯地平。当他重新开始治疗时,他的牙周评分有所改善。我们报告说,在不调整钙通道阻滞剂的情况下,通过基础牙周治疗、手术和持续强化随访,可以显著改善牙龈增生。

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